Whole-organ cardiac transplantation is the only currently available clinical means of replacing the lost muscle, but this option is limited by the inadequate supply of donor hearts. Given this, much attention has recently been directed at cell transplantation strategies as an alternate means of ameliorating cardiac injury :845-856 ; Dimmeler et al., 'Unchain My Heart: The Scientific Foundations of Cardiac Repair,' J Clin Invest 115 :572-583 ; Laflamme et al., 'Cell-Based Cardiac Repair: Pathophysiologic Mechanisms,' Annual Rev Pathol 2:307-39 ; Rubart et al., 'Cardiac Regeneration: Repopulating the Heart,' Annu Rev Physiol 68:29-49 ).
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