Apoptotic Caspases Suppress mtDNA-Induced Sting-Mediated Type I Ifn Production

Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the suggestion that caspases are activated not just to kill but to prevent dying cells from triggering a host immune response.

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