Experimental Gene Therapy Successful in Certain Lymphomas and Leukemia

Study results of CD19-directed chimeric antigen receptor therapy using the Sleeping Beauty non-viral transduction system to modify T cells has demonstrated further promise in patients with advanced hematologic malignancies. Patients who had acute lymphocytic leukemia , non-Hodgkin lymphoma or chronic lymphocytic leukemia were part of clinical trials at The University of Texas MD Anderson Cancer Center , which used the Sleeping Beauty gene transfer system initially discovered at the University of Minnesota.

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