[Report] Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution in the tail of histone H3.3. The role of the H3.3K27M mutation in tumorigenesis is not fully understood. Here, we use a human embryonic stem cell system to model this tumor.

http://ift.tt/1wIxyUF