E-mail: khattori@ims.u-tokyo.ac.jp Received 21 November 2013; Revised 1 April 2014; Accepted 21 April 2014 Accepted article preview online 5 May 2014; Advance online publication 3 June 2014 The systemic inflammatory response observed during acute graft-versus-host disease is driven by proinflammatory cytokines, a ‘cytokine storm’. The function of plasmin in regulating the inflammatory response is not fully understood, and its role in the development of aGVHD remains unresolved.
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