Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy. Epigenetic silencing of retroviral transgene expression in pluripotent stem cells and their differentiated progeny constitutes a major roadblock for PSC-based gene therapy.
http://ift.tt/1El8wMH
http://ift.tt/1El8wMH
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