Stem cell disease model reveals how tumor suppressor may drive bone cancer

Using induced pluripotent stem cells , a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances. The study results, published today in the journal Cell , revolve around iPSCs, which since their 2006 discovery have enabled researchers to coax mature bodily cells to become like embryonic stem cells .

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