Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia

Hairy cell leukemia is a chronic lymphoproliferative disorder characterized by somatic BRAFV600E mutations. The malignant cell in HCL has immunophenotypic features of a mature B cell, but no normal counterpart along the continuum of developing B lymphocytes has been delineated as the cell of origin.

http://ift.tt/1EUSLxF