Where cell fate conversions meet Chinese philosophy

Here, we further suggest that mammalian cells fall into two grand divisions, mesenchymal or epithelial; interconversions between these two grand divisions through EMT/MET resonate with some ancient Chinese philosophic ideas. When mammalian fibroblasts are reprogrammed to induce pluripotent stem cells they pass through MET, which overcomes a major roadblock on the pathway of reprogramming 3 .

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