Correspondence: Dr BL Stein, Northwestern University Feinberg School of Medicine, 645 N Michigan Avenue, Suite 1020, Chicago 60611, IL, USA. E-mail: brady-stein@northwestern.edu Received 17 February 2014; Revised 25 April 2014; Accepted 7 May 2014 Accepted article preview online 3 June 2014; Advance online publication 1 July 2014 Of the myeloproliferative neoplasms , myelofibrosis is associated with the greatest symptom burden and poorest prognosis and is characterized by constitutional symptoms, cytopenias, splenomegaly and bone marrow fibrosis.
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