Erythroid differentiation in chimaeric mice blocked by a targeted...

The zinc-finger transcription factor GATA-1 murine embryonic stem cell line and tested the GATA-1-deficient cells for their ability to contribute to different tissues in chimaeric mice. The mutant embryonic stem cells contributed to all non-haemopoietic tissues tested and to a white blood cell fraction, but failed to give rise to mature red blood cells.

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