New genomic editing methods produce better disease models from patient-derived iPSCs

Highly valuable for modeling human diseases and discovering novel drugs and cell-based therapies, induced pluripotent stem cells are created by reprogramming an adult cell from a patient to obtain patient-specific stem cells. Due to genetic variation, however, iPSCs may differ from a patient's diseased cells, and researchers are now applying new and emerging genomic editing tools to human disease modeling, as described in a comprehensive Review article published in Stem Cells and Development .

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