Idiopathic pulmonary fibrosis or IPF - where the disease appears spontaneously and without a known cause - is a severe, chronic lung disease in which the rapid growth of fibrous tissue results in increasingly severe breathing difficulties and a high mortality rate. Excessive signaling of the growth factor TGF-I2 is recognized as a central player in lung fibrosis, and its increased expression has been identified in both IPF patients and experimental models of the disease.
http://ift.tt/1xW4wyk
http://ift.tt/1xW4wyk
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