The differentiation of human pluripotent stem cells to the B-cell lymphoid lineage has important clinical applications that include in vitro modeling of developmental lymphogenesis in health and disease. Here, we first demonstrate the capacity of human induced pluripotent stem cells to differentiate into CD144+CD73?CD43/CD235a? cells, characterized as hemogenic endothelium, and show that this population is capable of differentiating to CD10+CD19+ B lymphocytes.
http://ift.tt/1DMp0eX
http://ift.tt/1DMp0eX
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