Pigs provide outstanding models of human genetic diseases due to the striking similarities to human anatomy, physiology and genetics, but progress with porcine genetic engineering has been hampered by the lack of germline-competent pig ES cells.
http://www.nature.com/cr/journal/v23/n1/full/cr2012176a.html
http://www.nature.com/cr/journal/v23/n1/full/cr2012176a.html
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