Highly efficient reprogramming to pluripotency and directed...

Cell stem cell , Vol. 7, No. 5. , pp. 618-630, doi:10.1016/j.stem.2010.08.012 Clinical application of induced pluripotent stem cells is limited by the low efficiency of iPSC derivation and the fact that most protocols modify the genome to effect cellular reprogramming.

http://www.citeulike.org/user/ford89/article/7941129