Physiological release of endogenous tau is stimulated by neuronal activity

Amy M Pooler 1 , Emma C Phillips 1 , Dawn H W Lau 1 , Wendy Noble 1 & Diane P Hanger 1 Diane P Hanger, Tel:+44 20 7 848 0041; Fax:+44 20 7 08 0017; E-mail: diane.hanger@kcl.ac.uk Propagation of tau pathology is linked with progressive neurodegeneration, but the mechanism underlying trans-synaptic spread of tau is unknown.

http://www.nature.com/embor/journal/v14/n4/full/embor201315a.html