In normal development, all cells turn off genes they don't need, often by attaching a chemical methyl group to the DNA, a process called methylation.
http://www.biosciencetechnology.com/news/2014/01/permanent-changes-brain-genes-may-not-be-so-permanent-after-all
http://www.biosciencetechnology.com/news/2014/01/permanent-changes-brain-genes-may-not-be-so-permanent-after-all
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