High-dose chemotherapy for germ cell tumors: do we have a model?

Introduction: Since the late nineties, the intensification of chemotherapy doses with hematopoietic stem cell rescue held promise for patients with advanced and poor prognosis germ cell tumors . High-dose chemotherapy has, nowadays, a recognized indication in the salvage setting of advanced GCTs and is steadily utilized worldwide.Areas covered: We evaluated the available data with the use of HDCT in these patients.

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