Scientists use stem cells to learn how common mutation in Asians affects heart health

Human induced pluripotent stem cell-derived cardiomyocytes from carriers of the genetic polymorphism 2*2 in the cardioprotective enzyme Aldehyde Dehydrogenase 2 are more susceptible to ischemic damage. The cardiac myofilament protein Troponin T is still expressed; however, iPSC-CMs show a significant increase of TUNEL-positive nuclei relative to total nuclei labeled with DAPI .

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