Telomere-regulating Genes and the Telomere Interactome in Familial Cancers

Telomeres are repetitive sequence structures at the ends of linear chromosomes that consist of double-stranded DNA repeats followed by a short single-stranded DNA protrusion. Telomeres need to be replicated each cell cycle and protected from DNA-processing enzymes, tasks that cells execute using specialized protein complexes such as telomerase , which aids in telomere maintenance and replication, and the shelterin complex, which protects chromosome ends.

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