Genetic causes underlying the disqualification of two elite American Standardbred pacers

A DNA mutation that can lead to horses being genetically male, but female in appearance, may explain at least two cases of controversial sexual identity, according to research led by professors from the Texas A&M College of Veterinary Medicine & Biomedical Sciences and published in PLOS Genetics . This type of genetic abnormality is caused by a mutation called DNA copy number variation , in which there are deletions and duplications in the genome typically larger than 50 base pairs.

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