Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

BackgroundRespiratory syncytial virus infects the lung epithelium where it stimulates the production of numerous host cytokines that are associated with disease burden and acute lung injury. Characterizing the host cytokine response to RSV infection, the regulation of host cytokines and the impact of neutralizing an RSV-inducible cytokine during infection were undertaken in this study.MethodsA549, primary human small airway epithelial cells and wild-type, TIR-domain-containing adapter-inducing interferon-? and mitochondrial antiviral-signaling protein knockout mice were infected with RSV and cytokine responses were investigated by ELISA, multiplex analysis and qPCR.

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