[Review] An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

In adult mammalian organisms, multiple tissues-including the skin, blood, stomach, and intestines-are entrapped in a state of permanent regeneration; older cells are constantly shed, and the tissue is continuously being regenerated from resident stem cells. This phenomenon of "tissue renewal" was appreciated by Leblond in 1956, but the underlying mechanism has been unclear.

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