Set of molecules found to link insulin resistance in the brain to diabetes

A key mechanism behind diabetes may start in the brain, with early signs of the disease detectable through rising levels of molecules not previously linked to insulin signaling, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai published today in the journal Cell Metabolism . Past studies had found that levels of a key set of protein building blocks, branched-chain amino acids , are higher in obese and diabetic patient, and that this rise occurs many years before someone develops diabetes.

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