Ataxia-telangiectasia is a neurodegenerative disorder caused by defects in the ATM kinase, a component of the DNA-damage response . Here, we employed an immortalized human neural stem-cell line capable of differentiating in vitro into neurons, oligodendrocytes and astrocytes to assess the ATM-dependent response and outcome of ATM ablation.
http://ift.tt/1uP9wJ1
http://ift.tt/1uP9wJ1
No comments:
Post a Comment