Recent studies have shown that differentiated cancer cells can dedifferentiate into cancer stem cells although to date no studies have reported whether this transition is influenced by systemic anti-cancer agents. Valproic acid is a histone deacetylase inhibitor that promotes self-renewal and expansion of hematopoietic stem cells and facilitates the generation of induced pluripotent stem cells from somatic cells and is currently being investigated in breast cancer clinical trials.
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http://ift.tt/1urrj8Y
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