Integrins are essential in stem cell binding to defective cartilage for joint regeneration

The promise for using mesenchymal stem cells to repair cartilage damage caused by osteoarthritis depends on the MSC being able to attach efficiently to the defective cartilage. A novel laboratory model in which artificially created cartilage lesions and labeled MSC were used to test factors that might improve MSC binding and the effectiveness of future MSC-based therapies is described in BioResearch Open Access , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers .

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