Mammalian Heart Regenerative Capacity Depends on Severity of Injury

A new study by researchers at Children's Hospital Los Angeles has shown that neonatal mouse hearts have varying regenerative capacities depending upon the severity of injury. Using cryoinjury - damaging the heart through exposure to extreme cold in order to mimic cellular injury caused by myocardial infarction - investigators found that neonatal mouse hearts can fully recover normal function following a mild injury, though fail to regenerate after a severe injury.

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