Optogenetics Reveal Delayed Afferent Synaptogenesis on Grafted...

Reprogramming of somatic cells into pluripotency stem cell state has opened new opportunities in cell replacement therapy and disease modeling in a number of neurological disorders. It still remains unknown, however, to what degree the grafted human-induced pluripotent stem cells differentiate into a functional neuronal phenotype and if they integrate into the host circuitry.

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