Species Extrapolation of Life-Stage Physiologically-Based...

Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo Methods a 1To whom correspondence should be addressed at Neurotoxicology Branch , Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711. E-mail: To provide useful alternatives to in vivo animal studies, in vitro assays for dose-response assessments of xenobiotic chemicals must use concentrations in media and target tissues that are within biologically-plausible limits.

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