MGMT-independent temozolomide resistance in pediatric glioblastoma...

Cancer research , Vol. 70, No. 22. , pp. 9243-9252, doi:10.1158/0008-5472.can-10-1250 Sensitivity to temozolomide is restricted to a subset of glioblastoma patients, with the major determinant of resistance being a lack of promoter methylation of the gene encoding the repair protein DNA methyltransferase MGMT, although other mechanisms are thought to be active.

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