Researchers Produce iPSC Model to Better Understand Genetic Lung/Liver Disease

Using patient-derived stem cells known as induced pluripotent stem cells to study the genetic lung/liver disease called alpha-1 antitrypsin deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease. The study, which appears in Stem Cell Reports , also found that liver cells derived from AAT deficient iPSCs are more sensitive to drugs that cause liver toxicity than liver cells derived from normal iPSCs.
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