Several signaling pathways including JAK-STAT, EGFR and Hippo pathways have been implicated in damage-induced ISC proliferation, but the mechanisms that integrate these pathways have remained elusive.
http://www.nature.com/cr/journal/v23/n9/full/cr2013101a.html
http://www.nature.com/cr/journal/v23/n9/full/cr2013101a.html
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