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Wednesday, November 26, 2014

iPS cells used to correct genetic mutations that cause muscular dystrophy

This image shows immunofluorescence staining of skeletal cells differentiated from DMD-iPS cells. Untreated DMD skeletal cells do not express dystrophin due to the deletion of exon 44. However, after any of the three correction strategies are applied to iPS cells, differentiation into skeletal cells results in normal dystrophin expression.

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