A protein called GRP78 could be a universal therapeutic target for treating human diseases like brain cancer, Ebola, Influenza, Hepatitis and superbug bacteria such as MRSE and MRSA, according to a Virginia Commonwealth University-led pre-clinical study published this month in the Journal of Cellular Physiology . By using a drug combination of the clinically tested OSU-03012 and FDA approved Phosphodiesterase 5 Inhibitors to target GRP78 and related proteins, researchers prevented the replication of a variety of major viruses in infected cells, made antibiotic-resistant bacteria vulnerable to common antibiotics and found evidence that brain cancer stem cells were killed.
http://medicalxpress.com/news/2014-12-protein-grp78-universal-therapeutic-multiple.html
http://medicalxpress.com/news/2014-12-protein-grp78-universal-therapeutic-multiple.html
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