Nuclear all-trans retinoic acid receptors initiate early transcriptional events which engage pluripotent cells to differentiate into specific lineages. RAR-controlled transactivation depends mostly on agonist-induced structural transitions in RAR C-terminus , thus bridging coactivators or corepressors to chromatin, hence controlling preinitiation complex assembly.
http://ift.tt/1AssAN8
http://ift.tt/1AssAN8
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