Culture clash: How stem cells are grown affects their genetic stability

The therapeutic promise of human stem cells is indisputably huge, but the process of translating their potential into effective, real-world treatments involves deciphering and resolving a host of daunting complexities. Writing in the February 25 online issue of the journal PLOS ONE , researchers at University of California, San Diego School of Medicine, with collaborators from The Scripps Research Institute , have definitively shown for the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.

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