Culture conditions in which stem cells are grown can affect genetic stability

The therapeutic promise of human stem cells is indisputably huge, but the process of translating their potential into effective, real-world treatments involves deciphering and resolving a host of daunting complexities. Writing in the February 25 online issue of the journal PLOS ONE , researchers at University of California, San Diego School of Medicine, with collaborators from The Scripps Research Institute , have definitively shown for the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.

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