In the last decade, many papers highlighted that the histone variant H2AX and its phosphorylation on Ser 139 cannot be simply considered a specific DNA double-strand-break marker with a role restricted to the DNA damage response, but rather as a 'protagonist' in different scenarios. This review will present and discuss an up-to-date view regarding the 'non-canonical' H2AX roles, focusing in particular on possible functional and structural parts in contexts different from the canonical DNA DSB response.
http://ift.tt/18thGgk
http://ift.tt/18thGgk
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