Stem Cell Roundup: April 2015

Thursday, April 23, 2015

'A Moratorium on Human Gene Editing Is Critical'

Rudolf Jaenisch, MD, is a Founding Member, Whitehead Institute for Biomedical Research, and President, the International Society for Stem Cell Research It has been just over a half-century since scientists solved the structure of DNA, and since that time, we have been fascinated by what the DNA encodes, how it is passed on from one generation to the next and what makes each of us unique. Technologies to introduce DNA changes have been used to study the function of genes and the proteins they encode, to identify genetic causes of disease and to develop better ways to treat them.
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Stem Cell Injection May Reverse Age-Related Vision-Loss, Researchers Reveal

A study published in the journal Stem Cell discovered that administering stem cells into the eye through injection can delay or prevent the effects of early-stage macular degeneration associated with ageing. According to lead researcher Shaomei Wang of Cedars-Sinai, their study is the first of its kind in terms of presenting a vision preservation with a single stem cell injection.
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Rejuvenation Biotechnology Update for Q2 2015

Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is medical biotechnology: progress towards repair and reversal of the known root causes of aging.
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Hamilton Thorne Reports Record Revenue; Operating Leverage Drives...

The Company's strategy to focus on its core markets continues to generate strong sales growth and substantial improvements in financial performance. Sales increased 16% to a record $8.7 million for the year, led by strong growth in sales of IVOS II image analysis products and LYKOS clinical laser systems, as well as increased revenues from after-sale services.
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Researchers in China have manipulated human embryos

Long a no-no in the scientific community, researchers in China have for the first time modified the DNA of a human embryo. Not surprisingly, other scientists are not happy about it.
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Modulating the Vascular Response to Limb Ischemia: Angiogenic and...

Correspondence to John P. Cooke, MD, Chair, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave, Mail Stop R10-South, Houston, TX 77030. E-mail The age-adjusted prevalence of peripheral arterial disease in the US population has been estimated to approach 12%.
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Chinese scientists first to genetically modify human embryos, critics lash out

In a move that is both groundbreaking and extremely controversial, a group of Chinese scientists released a study detailing their experiments with genetically engineered human embryos. Editing the DNA of humans has long been considered an ethical taboo in the field of science, and the experiments performed by Junjiu Huang and his colleagues at the Sun Yat-sen University in Guangzhou, China have been heavily criticized by both scientists and watchdog groups on the lookout for violations of human ethics.
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Caring for a family member with a terminal illness

One of the most challenging parts of life is to watch a loved one go through a serious illness, such as cancer . As adults, we find different ways to cope.
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First experiment 'editing' human embryos ignites ethical furor

... in a clinical setting," said MIT biologist Rudolf Jaenisch, president of the International Society for Stem Cell Research. Huang's experiments provide evidence of what can go wrong with CRISPR. His team experimented on 86 one-cell human embryos, ...
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School's website, blog, magazine win AAMC awards

... starts for hearts ," was written by Krista Conger , and describes the difficulties and possibilities of stem cell research and how the work may someday be used to repair damaged hearts. It also describes the impact of heart disease on a family in ...
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Human embryo 'editing' experiment sparks outcry

Looking to fossils to predict tooth evolution in rodents: Ever-growing molars in the future?

Fifty million years ago, all rodents had short, stubby molars -- teeth similar to those found in the back of the human mouth, used for grinding food. Over time, rodent teeth progressively evolved to become taller, and some rodent species even evolved continuously growing molar teeth.
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UPDATE 1-First experiment 'editing' human embryos ignites ethical furor

Looking to fossils to predict tooth evolution in rodents: Ever-growing molars in the future?

First experiment 'editing' human embryos ignites ethical furor

Chinese scientists use gene editing to modify human embryos

In an ethically charged first, Chinese researchers have used gene editing to modify human embryos obtained from an in-vitro fertilization clinic. The 16-person scientific team, based at the Sun Yat-Sen University in Guangzhou, China, set out to see whether it could correct the gene defect that causes beta-thalassemia, a blood disease, by editing the DNA of fertilized eggs.
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How to Grow a Regenerative Medicine Industry in Canada: Michael May of CCRM

April 23, 2015 There's a new kind of incubator in town. The Centre for Commercialization of Regenerative Medicine is a Canadian nonprofit that fosters hands-on association between academia, government, industry and investors to grow stem cell and regenerative medicine companies from the ground up.
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First experiment 'editing' human embryos ignites ethical furor

Tisch MS Research Center Of New York Reports Early Improvement In Stem Cell Trial

MS is a chronic autoimmune disease of the central nervous system where the myelin sheath is attacked and neurodegeneration may occur. It affects more than 2.3 million people worldwide.
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Study identifies molecular link between DNA damage and premature aging

Blocking the interferon pathway in mice with a premature aging condition improved their lifespan, body condition and fertility. Credit: University of Pennsylvania Like a beloved pair of jeans, human DNA accumulates damage over time, and older people's bodies can't repair it as well.
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Tales From City of Hope #5: My Stem Cells Have Come Home to Papa

It is 9:49 am PDT on April 24, and my stem cell transfusion is complete. It took less than 20 minutes.
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First experiment 'editing' human embryos ignites ethical furor

Scientists urge moratorium after Chinese researchers 'edit' human embryos

In a controversial new research paper, Chinese scientists describe how they were able to manipulate the genomes of human embryos for the first time, raising ethical concerns about this new frontier in science. First reported by Nature News on Wednesday, the paper appears in the little known online journal called Protein and Cell.
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Lung Institute Proud to Announce Treatment for Non-Congenital Bronchiectasis

The Lung Institute is proud to announce the ability to treat another debilitating lung condition. Bronchiectasis is a pulmonary condition in which damage to the airways causes them to widen and become scarred.
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[Report] Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

Although chicken soup and plenty of rest get most kids through an influenza virus infection, some require hospitalization. Ciancanelli et al. report on one child who suffered severely from influenza because of null mutations in the gene for transcription factor IRF7.
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a DNA-disaster or medical miracle? Chinese researchers modify human genome

For the first time ever, Chinese scientists report having successfully edited human embryos' genomes. The breakthrough has, however, also revived heated debate about the ethical feasibility of such experiments, which are feared to lead to eugenics.
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Scientists create first genetically modifed human embryos

While scientists often experiment with human adult cells and animal embryos, it's the first time a team has openly discussed working with human embryos. Sun Yat-Sen University researchers said they tried to eradicate the genes for a blood disorder called Beta Thalassemia in embryos that would have otherwise been discarded, according to their Protein & Cell journal article, published April 18. Using 86 embryos with extra sets of chromosomes that had been created for in vitro fertilization, the scientists in Guangzhou cut into DNA and either replaced or rewrote problematic genetic sequences.
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The Oncologist Release: Standard Clinical Assays Can Obscure The...

... significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.
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Chinese scientists 'edit' human embryos

Controversial Gene-Editing Approach Gains Ground

Mitochondria are biological dynamos. Damage to genetic material in these cellular powerhouses does more than sap energy - it can cause neurological disorders and derail central body functions such as motor control and sight.
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Scientists urge moratorium after Chinese 'edit' human embryos

... allowed scientists to investigate disease and develop new medical treatments," International Society for Stem Cell Research President Rudolf Jaenisch said in a statement, issued in response to the Chinese study on Thursday. "However, it is too soon ...
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Penn study identifies molecular link between DNA damage and premature aging

IMAGE: Blocking the interferon pathway in mice with a premature aging condition improved their lifespan, body condition and fertility. view more Like a beloved pair of jeans, human DNA accumulates damage over time, and older people's bodies can't repair it as well.
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Link between proteins points to possibilities for future Alzheimer's treatments

... disease mechanisms. Alzheimer's Research UK is committed to funding pioneering research and through our Stem Cell Research Centre at the University of Cambridge we hope to unpick the molecular changes that cause dementia, and crucially, to test new ...
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Evolution of stem cells traced in study of fossilized rodent teeth

By studying fossilized teeth from thousands of extinct rodent species, UC San Francisco and University of Helsinki scientists have shown how fundamental evolutionary mechanisms drive the emergence of novel mammalian stem cells. All currently existing rodent species have ever-growing front teeth, with crowns that are continually replenished as they are ground down by gnawing, but only some species have continuously growing molars.
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Scientists Edit Human Embryo Genes For First Time Ever: A Step Toward Disease-Free Future?

Researchers in China have confirmed they have for the first time in medical history succeeded in creating genetically modified human embryos. The team hopes their efforts will one day allow doctors to eradicate genetic diseases from fetuses before birth, but many feel that manipulating human DNA may open up Pandora's box.
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Tisch MS Research Center Of New York Reports Early Improvement In Stem Cell Trial

Tisch MS Research Center of New York today announced encouraging preliminary results from its FDA-approved Phase I trial using autologous neural stem cells in the treatment of multiple sclerosis . MS is a chronic autoimmune disease of the central nervous system where the myelin sheath is attacked and neurodegeneration may occur.
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Link between proteins points to possibilities for future Alzheimer's treatments

Why is Canada's life sciences sector flatlining?

A research assistant holds a petri dish containing an aggregate of human heart cells made from pluripotent stem cells at Toronto's Sick Kids Hospital on Tuesday November 25 2014. The Province of Ontario has announced the creation of an institute for regenerative medicine and three 'disease challenge teams' to bridge the widening gap in the province between basic research and clinically tested therapies that improve the health of patients with chronic and degenerative diseases.
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Fears arise as Chinese modify human embryo genes

Chinese scientists have successfully edited the genes of human embryos for the first time ever, confirming rumors that secret genetic experiments had been happening in the country and prompting fears that the Fears arise as Chinese modify human embryo genes Chinese scientists have successfully edited the genes of human embryos for the first time ever, confirming rumors that secret genetic experiments had been happening in the country and prompting fears that the Check out this story on WFAA.com: http://usat.ly/1Gl70fe A single cell is removed from a human embryo to be used in generating embryonic stem cells for scientific research.
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BioChain Institute, Inc. - Medical Equipment - Deals and Alliances Profile - New Market Report

The company designs, develops and markets diagnostic products. Its products include DNA panel, cDNA panel, DNA markers, genomic DNA, molecular weight markers, human stem cell cDNA library, small size genomic DNA, protein western blots, membrane protein, protein lysate, matched pair total protein, mitochondria isolation kit, and others.
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New Study: Olerup SSP Ab - Medical Equipment - Deals and Alliances Profile

The company develops kits for genomic HLA typing. Its products are used prior to a transplantation to match the donor and recipient.
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Scientists urge moratorium after Chinese 'edit' human embryos

Asian Nerve Repair & Regeneration Market - Analysis and Forecast to 2019 - New Study Released

The Asian Nerve repair and regeneration market is projected to grow at a CAGR of 11.7 % by 2019, which is driven by several factors such as technological advancements and an increasing number of neuro injuries that have provided a whole lot of growth opportunities for the market. In the Asian region, the maximum market share is held by Japan and China , due to the increasing diseases related to nerves such as Parkinson's and Epilepsy, as these are the major application areas for the devices , along with an increase in the population.
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Scientists bid to create GM embryos

The researchers used a molecular cut and paste technique to edit DNA at specific locations in order to remove and replace a problem gene The researchers used a molecular cut and paste technique to edit DNA at specific locations in order to remove and replace a problem gene A first attempt to create genetically modified human embryos has been made by Chinese scientists in a move that has prompted a call for a worldwide ban on the creation of "designer babies". The researchers used a molecular cut and paste technique to edit DNA at specific locations in order to remove and replace a problem gene.
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Scientists bid to create GM embryos

Chinese scientists 'edit' human embryos

RegMedNet shines light on use of stem cells as a potential Huntington's disease treatment

IMAGE: RegMedNet is a network that unites all members of this diverse community, enabling the connection and collaboration that will help this exciting field move forward at an even faster rate. view more 23 April, 2015 - Huntington's disease is an autosomal dominant neurodegenerative disease caused by a CAG triplet expansion in the Huntington gene, which causes progressive neuropsychiatric and motor dysfunction and leads to death.
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The ISSCR has responded to the publication of gene editing research in human embryos

In response to an article published by Chinese scientists describing research that used gene editing technologies in human embryos, the International Society for Stem Cell Research has again called for a moratorium on attempts at human clinical germline genome editing while extensive scientific analysis of the potential risks is conducted, along with broad public discussion of the societal and ethical implications. The research article, entitled "CRISPR/Cas9-mediated Gene Editing in Human Tripronuclear Zygotes," was published online on April 18 in the scientific journal Protein & Cell .
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Potential New Target to Prevent Breast Cancer Relapse

University of Adelaide researchers have discovered an important factor in the development of breast cancer and its spread, which may present a new target for treatment. Published in the journal Oncogene, the researchers have for the first time shown how a specific protein receptor on the surface of breast cells promotes the progression of breast cancer.
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Straus Taps House Team for Budget Negotiations

... oved by the House urged the conferees to maintain provisions from the House budget that block funding for stem cell research and sexual education providers that also provide abortions, namely Planned Parenthood.
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INDERMICA Skin Care Products Are Now Available at LEED Certified Epi Center MedSpa

Internationally recognized Cosmetic Dermatologist, Dr. Patrick Bitter, Sr. who developed the PhotoFacial and co-founded the renowned Epi Center MedSpa, recently announced the addition of INDERMICA skin care products. The INDERMICA products will not only be used during treatments at the Epi Center MedSpa, the nation's first original medical spa and sustainable LEED certified facility, but recommended for home-care use in order to enhance treatment results.
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Fears arise as Chinese modify human embryo genes

Chinese scientists have successfully edited the genes of human embryos for the first time ever, confirming rumors that secret genetic experiments had been happening in the country and prompting fears that the discovery could lead to a new kind of eugenics. The researchers were able to successfully modify a specific gene responsible for a potentially fatal blood disorder.
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Fears arise as Chinese modify human embryo genes

Chinese scientists have successfully edited the genes of human embryos for the first time ever, confirming rumors that secret genetic experiments had been happening in the country and prompting fears that the Fears arise as Chinese modify human embryo genes Chinese scientists have successfully edited the genes of human embryos for the first time ever, confirming rumors that secret genetic experiments had been happening in the country and prompting fears that the Check out this story on USATODAY.com: http://usat.ly/1Gl70fe In this file photo originally made available by Advanced Cell Technology, a single cell is removed from a human embryo to be used in generating embryonic stem cells for scientific research.
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Insulin Inhibits Cardiac Mesoderm, Not Mesendoderm, Formation During...

The study of the regulatory signaling hierarchies of human heart development is limited by a lack of model systems that can reproduce the precise developmental events that occur during human embryogenesis. The advent of human pluripotent stem cell technology and robust cardiac differentiation methods affords a unique opportunity to monitor the full course of cardiac induction in vitro.
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Stem cell treatment repairs birth defect, provides facial...

Researchers have pinpointed a primary cause of a rare skull disorder in infants, and the discovery could help wounded soldiers, car-wreck victims and other patients recover from disfiguring facial injuries. "This has a lot more implication than what we initially thought," said Yang Chai, a lead researcher on the study at the Herman Ostrow School of Dentistry of USC.
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New research targets breast cancer treatment and spread

WATCH: A Texas man gives chase and executes the perfect tackle after a thief tries to steal a bike from his garage. UPDATE: An Islamic school principal has denied he banned girls from running because of concerns it might cause them to lose their virginity.
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Researchers describe natural mechanism that helps repair lesions in teeth

... with modified platelets that do not produce serotonin or dopamine, i.e. in the absence of the signal. "In stem cell research, it is unusual to be simultaneously able to isolate cell lines, identify the markers that allow them to be recognised (here ...
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Wednesday, April 22, 2015

Stem Cell Symposium to Focus on Tissue Engineering, Limb Regeneration

Limb regeneration, stem cells, limb development, tissue engineering: These will be the focus of the 10th Annual Wisconsin Stem Cell Symposium on Wednesday, April 22, hosted by the University of Wisconsin-Madison Stem Cell and Regenerative Medicine Center and the BioPharmaceutical Technology Center Institute . This year, UW-Madison scientists and other American and international researchers will come together at the BTCI campus in Fitchburg, Wisconsin, to present the latest in limb regeneration science.
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UCLA researchers issued patent for method that helps validate stem cells created in a lab

Two UCLA stem cell researchers have received a patent for their method of verifying that stem cells created in a lab using adult donor cells have potentially reached a pluripotent state, which means they are capable of turning into any other cell in the body. The patent was issued to William Lowry and Kathrin Plath of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research for their work using a tumor rejection antigen, or TRA, to identify stem cells that have pluripotent characteristics.
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Cambridge researchers use stem cells to unlock new Alzheimer's development

Scientists from Cambridge University were able to 'reprogramme' skin cells from individuals with the genetic form of the debilitative disease, in order to mimic the condition. Dr Simon Ridley, Head of Research at Alzheimer's Research UK, which funded the study, said: "We are pleased to see that our investment in this innovative research using stem cell technology is boosting our understanding of Alzheimer's disease mechanisms."
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Calorie Restriction Makes Old Muscle Metabolism More Youthful

The rumors were true: Scientists edited the genomes of human embryos for the first time

In March, a rumor surfaced in the scientific community that was intriguing, and perhaps a bit chilling: According to those in the know, researchers in China had successfully edited the genomes of human embryos, altering their DNA in a way never accomplished in our own species. MIT Technology Review reported on the murmurings that someone had altered the germ line -- the genetic information that come together and form something new when eggs and sperm collide.
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Haircuts Help Family Fighting Cancer

A Des Moines family got a difficult diagnosis last month. Now, friends are rallying to show support with a relaxing way people can help.
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Straus Taps House Team for Budget Negotiations

Chinese Scientists Genetically Modify Human Embryos

In a world first, Chinese scientists have reported editing the genomes of human embryos. The results are published in the online journal Protein & Cell and confirm widespread rumours that such experiments had been conducted - rumours that sparked a high-profile debate last month about the ethical implications of such work.
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Stem cells that prevent birth defect also repair facial injury

In World First, Scientists Genetically Modify Human Embryos

Researchers at Sun Yat-sen University in Guangzhou have edited the genomes of human embryos, Nature reported in an exclusive Wednesday. The study , which was published in the journal Protein & Cell , confirms rumors that some scientists were conducting these ethically dubious experiments.
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Stem cells that prevent birth defect also repair facial injury

Cancer scan could remove need for radiotherapy for cured patients

A UK National Cancer Research Institute trial led from The University of Manchester and the Christie NHS Foundation Trust has suggested that in patients with early stage Hodgkin lymphoma the late effects of radiotherapy could be reduced by using a scan to determine those who actually need it. In a paper published in the New England Journal of Medicine , the scientists show that a positron-emission tomography scan immediately after treatment with chemotherapy can identify patients who have a very good outcome without additional radiotherapy.
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Speaker Joe Straus on April 17th, 2015 during debate of HB 910

Chinese scientists genetically modify human embryos

In a world first, Chinese scientists have reported editing the genomes of human embryos. The results are published 1 in the online journal Protein & Cell and confirm widespread rumours that such experiments had been conducted-rumours that sparked a high-profile debate In the paper, researchers led by Junjiu Huang, a gene-function researcher at Sun Yat-sen University in Guangzhou, tried to head off such concerns by using 'non-viable' embryos, which cannot result in a live birth, that were obtained from local fertility clinics.
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Researchers discover new drugs to combat the root cause of multiple sclerosis

Several drugs could lead to new treatment options for multiple sclerosis, including two drugs that effectively treat MS at the source, in vivo, researchers report. At the pathological level, MS is a disease in which the immune system attacks the protective myelin sheath, a type of insulation that covers nerves, ultimately disrupting communication between the brain and the body and leading to nerve deterioration.
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Associate Director of Pro-Life - Diocese of Austin

... and instruction of Catholics and the general public on life issues (abortion, post-abortion and healing, stem cell research, human cloning, bioethical issues, euthanasia, end-of-life care, and the death penalty). Promote advocacy efforts of Diocese ...
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Verastem, Inc. Presents Encouraging Scientific Data On The...

Verastem, Inc. , focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, today announced the presentation of scientific data at the 2015 American Association of Cancer Research Annual Meeting being held April 18-22, 2015 at the Pennsylvania Convention Center in Philadelphia, PA.
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BioInvent Interim Report 1 January ??? 31 March 2015

"The key to the Company's value creation is our own clinical projects. We are therefore working intensely to create a significantly more mature project portfolio.
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Neuromics, Inc. - Medical Equipment - Deals and Alliances Profile - New Market Study Published

The company provides reagents and methods for the neuroscience and stem cell research community. It operates through various business categories such as Antibodies, Apoptosis, Neurons, Cell Based Assays, Proteins-Molecules, Purify-Label, Stem Cells, and Transfection.
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Stem cell treatment may signal cure for genetic diseases

Stem cells are viewed on a computer screen at the University of Connecticut`s Stem Cell Institute at the UConn Health Center on August 27, 2010 in Farmington, Connecticut. BRITISH doctors have cured children of a deadly inherited disorder using a ground-breaking stem cell treatment that heralds a new dawn for genetic therapies.
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Alumna, pioneer in cardiovascular cell therapy to speak at MUW graduation

Mississippi University for Women alumna Dr. Doris Taylor, a pioneer in cardiovascular cell therapy research, will address Mississippi University for Women graduates in Rent Auditorium on Saturday, May 9. Taylor, director of regenerative medicine research at the Texas Heart Institute in Houston, also will be awarded an honorary doctorate, the university's highest honor, at its morning commencement exercises that day. Credited with a number of scientific breakthroughs related to cell therapy, stem cell biology and tissue engineering, Taylor also serves as director of the Center for Cell and Organ Biotechnology at the Texas Heart Institute and Texas A&M College of Veterinary Medicine and Biomedical Sciences.
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Seven days: 17-23 April 2015

The week in science: Nobel laureate leads stem-cell initiative; German science gets a boost; and comet spews dust from its dark side. Research boost In a deal announced on 16 April, Germany's ruling political parties agreed to increase funding for science by a 5 billion between 2018 and 2028.
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Gene Therapy Shows Promise for Rare Immune Disorder

Gene therapy may benefit children and teens with a rare immune disorder called Wiskott-Aldrich syndrome, a small study finds. The disorder - characterized by low blood platelet count, eczema and recurring infections - is caused by mutations in what's known as the WAS gene.
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MIT receives $1.7 million for study of Down syndrome from Alana Foundation

MIT and Case Western Reserve University have each received $1.7 million from Brazil's Alana Foundation to develop a collaboration that will help advance our understanding of Down syndrome. The work could ultimately lead to new therapies for the genetic condition, improving the quality of life for persons born with it.
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Regeneus (ASX:RGS) Receives Approval For Progenza OA Trial

Regeneus , a clinical stage regenerative medicine company focused on the development of cell therapies, announced today that it has received ethics approval for a clinical trial of its new off-the-shelf allogeneic stem cell treatment, known as Progenza, for patients with knee osteoarthritis. Progenza is produced from adipose tissue from a healthy donor who has been extensively screened.
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Natural reparative capacity of teeth elucidated

... the natural reparative capacity of the teeth. Credit: Inserm / Odile Kellermann, Anne Baudry "In stem cell research , it is unusual to be simultaneously able to isolate cell lines , identify the markers that allow them to be recognised (here ...
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Mechanism of action of two new synthetic drugs unravelled for the first time

Substances such as 4-MEC and 4-MEPP belong to the category of new hybrid cathinone derivatives and have a highly stimulant and euphoria-inducing effect, similar to the synthetic drug mephedrone, which was banned in Austria five years ago. Until now, the mechanisms by which these two drugs worked have been unknown.
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International Stem Cell Corp. (ISCO) Demonstrates Treatment of...

April 22, 2015 Today before the opening bell, International Stem Cell Corp., a biotechnology company developing novel stem cell based therapies and biomedical products, announced publication of results of two proof-of-concept studies that validate the safety and efficacy of the company's readily expandable stem cell derived treatment of Parkinson's disease in both non-human primate and rodent animal models. "The publication of these data in the peer-reviewed and highly-respected journal, Cell Transplantation, brings to a conclusion the preclinical stage of our Parkinson's disease program.
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Protein Adseverin identified as key factor driving bone loss in osteoinflammatory disease

Adseverin, a protein found in the body, has been identified as the key driver behind the bone loss associated with the world's most common inflammatory disease: gum disease, or periodontitis. The findings, published this month in top biology journal FASEB by researchers at the University of Toronto's Faculty of Dentistry, paves the way for new preventive treatment models for this prevalent disease.
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Researchers discover new drugs to combat the root cause of multiple sclerosis

New research published this week in Nature has found several drugs could lead to new treatment options for multiple sclerosis , including two drugs that effectively treat MS at the source, in vivo. When administered at the peak of disease, these two drugs showed a striking reversal of disease severity.
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Silicon Valley's Cellular Biomedicine Group Expands in Beijing With New Facility and Plans to Hire

Cellular Biomedicine Group Inc. , a biomedicine firm engaged in the development of effective treatments for degenerative and cancerous diseases, today announced that the Company, in anticipation of growth in the Beijing vicinity and further development of the CAR-T platform, has signed a new five-year lease for a 15,000 square feet site slated for the Company's third GMP facility which will also expanded staffing in the Life Science Park, Changping District, Beijing, China. Approximately half of the site will be a GMP equipped facility to support clinical batch production and commercial scale manufacturing.
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BioTime Licenses Beckman Research Institute of City of Hope to Manufacture Clinical Grade Stem Cells

BioTime, Inc. today announced a nonexclusive License Agreement between BioTime's subsidiary ES Cell International Pte Ltd and Beckman Research Institute of the City of Hope through which ESI's clinical-grade human embryonic stem cells will be manufactured and provided to BRICOH's clinical collaborators, including medical research organizations intent on using the hES cells to develop and commercialize therapeutic products to treat human disease.
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Natural reparative capacity of teeth elucidated

Researchers Discover New Drugs to Combat the Root Cause of Multiple Sclerosis

For one patient and possibly for many, cancer trial shows promising results

A year ago, Meagan Mullanix was waiting to see whether the experimental therapy would work, whether her own genetically reprogrammed immune-system cells could truly target and destroy the cancer that nearly killed her. Today, the 23-year-old returning college student is cancer-free, with no evidence of the acute lymphoblastic leukemia, or ALL, that first struck when she was 17, and then came raging back-even after chemotherapy treatments and a bone-marrow transplant.
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Cellular Biomedicine Group Announces New Facility in Beijing

A new lease on life for prostate tissue

What if a prostate cancer patient could learn which anti-cancer treatments would work best for him without having to swallow a single pill or endure a single intravenous line or injection? Research from Rutgers Cancer Institute of New Jersey involving the development of human organoid prostate models could have implications for how future therapy is guided for some of this population, say investigators. At focus is the development of prostate stem cell-derived organoids, the size of a pinhead, that were developed from prostate cancer biopsy and resected tissue taken from patients with early-stage and advanced prostate cancer.
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Graft versus Host Disease conference, UH Fairlawn open house: free health events

A day-long national medical symposium on Graft versus Host Disease will be held on Friday, April 24, at Embassy Suites Cleveland, 5800 Rockside Woods Blvd., Independence. Designed to raise awareness about the signs and symptoms of GvHD - a complication that can occur after a stem cell or bone marrow transplant - the conference, in its fifth year, will feature a series of sessions that are free to patients and caregivers.
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Gene therapy reduces infectious complications in children, teens with Wiskott-Aldrich syndrome

In a small study that included seven children and teens with Wiskott-Aldrich syndrome, a rare immunodeficiency disorder, use of gene therapy resulted in clinical improvement in infectious complications, severe eczema, and symptoms of autoimmunity, according to a study in the April 21 issue of JAMA, a theme issue on child health. Wiskott-Aldrich syndrome is caused by loss-of-function mutations in the WAS gene.
http://ift.tt/1bim8zk

REVLIMID (lenalidomide) now available in UK for adult patients with...

REVLIMID now available in UK for adult patients with previously untreated multiple myeloma who are not eligible for transplant Celgene Limited, a wholly owned subsidiary of Celgene Corporation, has announced that REVLIMID is now available for adult patients with previously untreated multiple myeloma who are not eligible for stem cell transplant.
http://ift.tt/1btY2lR

New drug combination shows promise for breaking breast cancer resistance

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer . In research to be revealed at the American Association of Cancer Research annual conference on Monday, the researchers show that in the most common type of breast cancer, affecting 70% of patients, the drug Sulforadex helps overcome resistance to routinely used hormonal treatments by targeting the cancer stem cell population.
http://ift.tt/1yODhvq

Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis

A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis . Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory.
http://ift.tt/1G61JFZ

Stem cell scientists develop more effective way to create motor neurons

Often described as the final frontier of biology, the nervous system is a complex network comprised of the brain, spinal cord and the nerves that run through the body. Published today by scientists led by Bennett Novitch, Ph.D. at the Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, new research using embryonic stem cells enhances the study of this intricate and perplexing system.
http://ift.tt/1IGSbUF

James Shapiro's latest research could soon mark new standard for diabetes treatment

James Shapiro, one of the world's leading experts in emerging treatments of diabetes, can't help but be excited about his latest research. The results he says, could soon mark a new standard for treatment--not only in diabetes, but in several other diseases as well.
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U...O1U O U O O U O O Uso O U O O O U O Uoeusuoe Uoeo U U O O U O U...O O U O O O Uoeo U O Uoeu Uoeo U

Qatar Biomedical Research Institute , a research and development entity under Qatar Foundation for Education, Science and Community Development , has announced the launch of a new internship initiative, the 'Summer Research Programme' . Running over eight weeks from 10 May to 2 July, the programme is open to undergraduate students from local, regional, and international universities.
http://ift.tt/1DAeqag

Asymmetrex Interviewed in Anticipation of Presentations at the 14th...

... to tissue stem cells, that it can be used to identify them, which is a long-standing unmet need in tissue stem cell research and medicine. Asymmetrex's patented technologies for producing, identifying, and counting adult tissue stem cells for ...
http://ift.tt/1DM60zS

Tuesday, April 21, 2015

Cantrixil Receives Orphan Drug Designation from FDA

Orphan Drug Designation is an important development for any experimental drug and has been instigated in a number of territories including the U.S, Cantrixil was granted Orphan Drug Designation under the U.S. Orphan drug Act following a review by the FDA of a package of pre-clinical data submitted by the Company.
http://ift.tt/1OEecFn

The Dearth of Altruism, the Calculation of Self-Interest

Skin medicines could help to fight multiple sclerosis - study

Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating around neurons that is damaged in diseases such as multiple sclerosis. Medicines used to help cure skin problems might prove to be vital in the fight against multiple sclerosis.
http://ift.tt/1Gg41Vo?

where I have been

... as information on the book which is essentially my life work. Sadly, we just lost a great champion of stem cell research: A. Alfred Taubman, who provided the funding for Michigan's Amendment 2, which made embryonic stem cell research legal in the ...
http://ift.tt/1IEg5jK

UAlberta research reveals new possibilities for islet and stem cell transplantation

Tales From City of Hope #2: Chemo Has Started

It is 10:43 am PDT on April 21, 2015. It is Day -2 and my final round of chemotherapy has officially started.
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Study shows feasibility of using gene therapy to treat rare immunodeficiency syndrome

In a small study that included seven children and teens with Wiskott-Aldrich syndrome, a rare immunodeficiency disorder, use of gene therapy resulted in clinical improvement in infectious complications, severe eczema, and symptoms of autoimmunity, according to a study in the April 21 issue of JAMA , a theme issue on child health. Wiskott-Aldrich syndrome is caused by loss-of-function mutations in the WAS gene.
http://ift.tt/1HR8HDl

Researchers Produce iPSC Model to Better Understand Genetic Lung/Liver Disease

Using patient-derived stem cells known as induced pluripotent stem cells to study the genetic lung/liver disease called alpha-1 antitrypsin deficiency, researchers have for the first time created a disease signature that may help explain how abnormal protein leads to liver disease. The study, which appears in Stem Cell Reports , also found that liver cells derived from AAT deficient iPSCs are more sensitive to drugs that cause liver toxicity than liver cells derived from normal iPSCs.
http://ift.tt/1aPBvPf

Study shows feasibility of using gene therapy to treat rare immunodeficiency syndrome

In a small study that included seven children and teens with Wiskott-Aldrich syndrome, a rare immunodeficiency disorder, use of gene therapy resulted in clinical improvement in infectious complications, severe eczema, and symptoms of autoimmunity, according to a study in the April 21 issue of JAMA , a theme issue on child health. Wiskott-Aldrich syndrome is caused by loss-of-function mutations in the WAS gene.
http://ift.tt/1bfYi7q

Drugs That Activate Brain Stem Cells May Reverse Multiple Sclerosis

Two drugs already on the market - an antifungal and a steroid - may take on new roles as treatments for multiple sclerosis . According to a study published April 20 in Nature , researchers have discovered that these drugs may activate stem cells in the brain to stimulate myelin-producing cells and repair white matter, which is damaged in MS.
http://ift.tt/1IDiM57

Nodality Publishes Study Results Confirming the Company's...

SCNP is a multiparametric flow cytometry-based platform that provides robust, human cell-based translational models of disease, drug activity and patient responses, and the company is focused on applying SCNP to solve drug development and treatment challenges. Nodality's classifier is designed to aid clinicians in treatment options by providing predictive information concerning the likelihood of patients achieving a complete response to standard induction therapy.
http://ift.tt/1cWdure

Study Shows Feasibility of Using Gene Therapy to Treat Rare Immunodeficiency Syndrome

Viral proteins may regulate human embryonic development

A fertilized human egg may seem like the ultimate blank slate. But within days of fertilization, the growing mass of cells activates not only human genes but also viral DNA lingering in the human genome from ancient infections.
http://ift.tt/1Qfmbwg

What happens when multiple sclerosis patients stop taking their medication?

Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion.
http://ift.tt/1E6JOBZ

Cantrixil Highly Successful In Preventing Growth Of Chemo-Resistant Ovarian Cancer

The data was presented by Professor Development of chemo-resistance is a major hurdle in the management of patients with ovarian cancer and this phenomenon is responsible for the high mortality associated with this disease. Growing evidence suggests that chemo-resistance is due to the presence in the tumor of a population of cancer cells with stem cell-like properties that are inherently drug-resistant, surviving radiotherapy and chemotherapy to produce a recurrent cancer re-populated with a new generation of chemo-resistant cancer cells.
http://ift.tt/1aOSFMW

Drugs that Activate Stem Cells May Reverse Multiple Sclerosis

The study was partially funded by the National Institute of Neurological Disorders and Stroke , part of the National Institutes of Health. Specialized cells called oligodendrocytes lay down multiple layers of a fatty white substance known as myelin around axons, the long "wires" that connect brain cells.
http://ift.tt/1yOqI3k

Pfizer's Inotuzumab Ozogamicin Phase 3 Study Meets Primary Endpoint

Pfizer today announced that the Phase 3 study investigating the treatment of inotuzumab ozogamicin met its first primary endpoint of demonstrating a higher complete hematologic remission rate in adult patients with relapsed or refractory CD22-positive acute lymphoblastic leukemia compared to that achieved with standard of care chemotherapy. The Phase 3 study has two primary endpoints, complete hematologic remission rate and overall survival.
http://ift.tt/1HeNkNh

The 8th Sacrament

... about following the Church teachings on some more serious subjects like abortion, euthanasia or embryonic stem cell research. On her deathbed St. Therese of Lisieux worried that the other members of her order would grieve too much over her death. ...
http://ift.tt/1Hf3jux

Drugs Stimulate Body??'s Own Stem Cells To Replace The Brain Cells...

Drugs Stimulate Body's Own Stem Cells To Replace The Brain Cells Lost In Multiple Sclerosis A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis. Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory.
http://ift.tt/1IC7Og6

Pfizer Phase 3 Study Of Inotuzumab Ozogamicin Meets Primary Endpoint...

ALS Stem Cell Treatment Shows Effectiveness in Trial

Israel's BrainStorm Cell Therapeutics said a mid-stage clinical trial of its adult stem cell treatment showed a "statistically significant" effect in patients with amyotrophic lateral sclerosis . According to the ALS Association, 5,600 people in the United States are diagnosed each year with the neurodegenerative disease, also known as Lou Gehrig's Disease, which has severely disabled British physicist Stephen Hawking.
http://ift.tt/1Jq8AwU

International Stem Cell Corporation Publishes Results Demonstrating...

"The publication of these data in the peer-reviewed and highly-respected journal, Cell Transplantation , brings to a conclusion the preclinical stage of our Parkinson's disease program. The data clearly support the premise that parthenogenetic neural stem cells can be effective in treating the symptoms of Parkinson's disease and, along with the previously reported safety data, forms the basis of our decision to move into the clinic," said Ruslan Semechkin, Ph.D., the Company's Chief Scientific Officer.
http://ift.tt/1PaMsdL

BrainStorm Cell Therapeutics Inc. Says Stem Cell Drug Benefits ALS Patients in Mid-Stage Trial

BrainStorm's NurOwnA Demonstrates a Statistically Significant Effect in ALS Patients Phase 2a Results and New Analyses Presented at American Academy of Neurology /PRNewswire/ -- BrainStorm Cell Therapeutics Inc. , a leading developer of adult stem cell technologies for neurodegenerative diseases, is presenting results from its phase 2a study of NurOwnA in amyotrophic lateral sclerosis at a poster session today at the American Academy of Neurology annual meeting, taking place in Among the new results is a piecewise linear regression analysis of all subjects who received intrathecal administration in the phase 2a study and the prior phase 1/2 study.
http://ift.tt/1aO0jae

My mum died after praying she would get cancer instead of me

When Lisa Parsons told her mum Lila she had breast cancer, she would pray to take the cancer away from her - and to have it herself She told her daughter that she would pray to take the cancer away from her - and to have it herself. And in what could be seen as a tragic fulfilment of her prayers, just three months later Lisa's mum Lila was diagnosed with cancer too.
http://ift.tt/1G2YTkV

Stem cell pioneer Elaine Fuchs wins cell biologists' highest science honor

... Systems Biology Department at Harvard Medical School. "She has made skin perhaps the best model for adult stem cell research beyond plants to general questions in cancer and in development. The direct clinical relevance of her research is ...
http://ift.tt/1G33rrH

Stem Cells Pioneer Elaine Fuchs Wins Cell Biologists' Highest Science Honor

BrainStorm's NurOwn Demonstrates a Statistically Significant Effect in ALS Patients

BrainStorm Cell Therapeutics Inc. , a leading developer of adult stem cell technologies for neurodegenerative diseases, is presenting results from its phase 2a study of NurOwn in amyotrophic lateral sclerosis at a poster session today at the American Academy of Neurology annual meeting, taking place in Washington D.C. In addition to previously disclosed topline results, further data and analyses are being presented for the first time today. Among the new results is a piecewise linear regression analysis of all subjects who received intrathecal administration in the phase 2a study and the prior phase 1/2 study.
http://ift.tt/1IBAJRp

Israel's BrainStorm says stem cell drug benefits ALS patients

New combination therapy could overcome treatment resistance, relapse in breast cancer

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer. In research to be revealed at the American Association of Cancer Research annual conference on Monday, the researchers show that in the most common type of breast cancer, affecting 70% of patients, the drug Sulforadex helps overcome resistance to routinely used hormonal treatments by targeting the cancer stem cell population.
http://ift.tt/1cUzT8p

Research and Markets: Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report

Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. In addition, their unspecialized nature allows them to differentiate into a wide variety of specialized cell types.
http://ift.tt/1Oa6urD

Two existing drugs may reverse damage caused by multiple sclerosis

A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis. Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory.
http://ift.tt/1K1c7me

Cell type responsible for scarring, skin-cancer growth identified by Stanford scientists

A skin cell responsible for scarring, and a molecule that inhibits the cell's activity, have been identified by researchers at the Stanford University School of Medicine. The researchers also found that the cell may play a role in the growth of melanoma and in skin damage caused by radiation.
http://ift.tt/1cUlIAh

Winnipeg to host Canadian Medical Hall of Fame inductions

Downtown Winnipeg will be at the centre of medical excellence this week as the Canadian Medical Hall of Fame , in association with the University of Manitoba, pays tribute to six medical pioneers for their extraordinary contributions to improving the health of Canadians and people worldwide. The University of Manitoba is proud to be hosting the 17th Canadian Medical Hall of Fame induction ceremony on April 23 at the Metropolitan Entertainment Centre for the second time in the CMHF's 41-year history.
http://ift.tt/1aMERlZ

Monday, April 20, 2015

Reinvigorated Vivian Campbell back on the road with Def Leppard after cancer battle

As a hard-rock guitarist, sure, he thought there was a certain amount of power in those long, flowing locks he'd grown since he was an 11-year-old and first introduced to the majesty of the heavenly maned Marc Bolan on TV. But now, at the age of 52, the Irish-born member of classic rockers Def Leppard has an entirely different perspective on things.
http://ift.tt/1HNPsdR

Supercentenarians Awards: $1 Million for the First 123-Year-Old

Pioneering A 110,000 stem cell trial treatment saved the life of an army medic

Ex army medic Katrina Brown and her friends raised A 110,000 to send her for pioneering stem cell treatment in the US - which is finally now A available on the NHS When army medic Katrina Brown returned from a three-month tour in Basra, Iraq, in 2003 she was relieved to get home safe and sound.. but four years later she began to feel ill.
http://ift.tt/1yMtI05

Long Non-Coding RNAs Control Hematopoietic Stem Cell Function

Cell Stem Cell , Vol. 16, No. 4. , pp. 426-438, doi:10.1016/j.stem.2015.02.002 Hematopoietic stem cells possess unique gene expression programs that enforce their identity and regulate lineage commitment.
http://ift.tt/1IzazP7

CML guidelines highlight need for TKI switch timing, choice

A review of the European LeukemiaNet guidelines on the care of patients with chronic myeloid leukaemia highlights the need for research into the timing and use of second-line and third-line tyrosine kinase inhibitors . The ELN guidelines, most recently published in 2013, are created by an international expert panel and revised every 3 years, explain Gianantonio Rosti and co-authors, from the University of Bologna in Italy, in the review published in the Annals of Hematology .
http://ift.tt/1J3Ktal

New drug combination shows promise for breaking breast cancer resistance

A new combination of drugs has been developed that may overcome treatment resistance and relapse in breast cancer. While most women initially respond well to hormonal treatment with drugs such as tamoxifen, many go on to develop resistance and relapse.
http://ift.tt/1HMVN9o

Early Human Embryos Make Viral Proteins

Human embryos make viral proteins within days of fertilization, a new study shows. These proteins affect human gene expression and may protect the cells from infection by other viruses.
http://ift.tt/1cS8BzD

New drug combination shows promise for breaking breast cancer resistance

Reinnervate Limited Release: Alvetex 3D Cell Culture Platform Reaches ...

Market leading 3D cell culture company Reinnervate Ltd, part of the ReproCELL group, today announced that a rocket carrying its AlvetexA Scaffold technology blasted into Space this week. Alvetex will be used in experiments on board the International Space Station .
http://ift.tt/1El22BH

Case Western Reserve University Release: Drugs Stimulate Body??'s Own ...

April 20, 2015 -air of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis. Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory.
http://ift.tt/1D8ntA8

Sulforaphane regulates self-renewal of pancreatic cancer stem cells...

Sulforaphane , a component of dietary cruciferous vegetables has been characterized for its anti-proliferative properties. We have recently demonstrated that pancreatic CSCs display activation of sonic hedgehog pathway which are fundamental drivers of stem cell renewal, and SFN inhibits the self-renewal of pancreatic CSCs in vitro.
http://ift.tt/1cS8BiZ

The two active X chromosomes in female ESCs block exit from the...

The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network. Cell stem cell , Vol.
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U of M investigates doctor's possible role in stem-cell research

Doug Broeska, centre, stands with Julia Browning, right. Seated are Sharon Nordstrom, left, and Kathleen Jaynes, far right.
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New drug combination shows promise for breaking breast cancer resistance

Could a Non-Prescription Antifungal Become a Major Advance for Multiple Sclerosis?

Dennis Bourdette, who chairs the department of neurology at Oregon State Health University and directs the university's Multiple Sclerosis and Neuroimmunology Center, puts it this way: All medications currently used to treat multiple sclerosis are anti-inflammatory. They control the abnormal immune response that attacks and destroys myelin in the brain and spinal cord.
http://ift.tt/1QbdZgp

Drugs Help Multiple Sclerosis Survivors Create New Stem Cells To Replace Lost Brain Cells

Multiple sclerosis is a devastating neurological disorder that, without a cure, leaves millions helplessly disabled to varying degrees of severity. But a new verge in medical discovery may have opened the doors of hope, thanks to a collaborative research team led by neuroscientists at Case Western Reserve University.
http://ift.tt/1DEKY6e

New drug combination shows promise for breaking breast cancer resistance

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer. In research to be revealed at the American Association of Cancer Research annual conference on Monday, the researchers show that in the most common type of breast cancer, affecting 70% of patients, the drug Sulforadex helps overcome resistance to routinely used hormonal treatments by targeting the cancer stem cell population.
http://ift.tt/1F7IbEU

Seattle Genetics, Inc. Release: FDA Accepts Supplemental BLA And...

Seattle Genetics, Inc. announced today that the U.S. Food and Drug Administration has accepted for filing a supplemental Biologics License Application for ADCETRIS in the AETHERA setting for the post-transplant consolidation treatment of Hodgkin lymphoma patients at high risk of relapse or progression. The FDA granted Priority Review for the application and the Prescription Drug User Fee Act target action date is August 18, 2015.
http://ift.tt/1Gdk4pW

Viral proteins may regulate human embryonic development

Philanthropist, shopping mall developer Taubman dies at 91

... traveled to Hungary to figure out why the country's sausage was so good. He also became a major backer of stem cell research. But it was his rearrangement of how people shop - parking lot in front, several stores in one stop close to home - that ...
http://ift.tt/1H9dAsm

Two existing drugs may potentially become new drug target for multiple sclerosis

Two drugs already on the market -- an antifungal and a steroid -- may potentially take on new roles as treatments for multiple sclerosis. According to a study published in Nature today, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis.
http://ift.tt/1O8nUVz

New Drug Combination Shows Promise for Breaking Breast Cancer Resistance

Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer. In research to be revealed at the American Association of Cancer Research annual conference on Monday, the researchers show that in the most common type of breast cancer, affecting 70% of patients, the drug Sulforadex helps overcome resistance to routinely used hormonal treatments by targeting the cancer stem cell population.
http://ift.tt/1G0S8QC

Repair damaged nerves in multiple sclerosis by stimulating body's own stem cells

... replace the cells lost in multiple sclerosis," says Paul Tesar, PhD, senior author of the Nature paper. Stem cell research in regenerative medicine has focused on direct transplantation of stem cell-derived tissue. "But here we asked if we could ...
http://ift.tt/1E2OXuU

FDA Accepts Supplemental BLA and Grants Priority Review for ADCETRIS...

FDA Accepts Supplemental BLA and Grants Priority Review for ADCETRIS in the AETHERA Setting for the Post-Transplant Consolidation Treatment of Hodgkin Lymphoma Patients at High Risk of Relapse Seattle Genetics, Inc. announced today that the U.S. Food and Drug Administration has accepted for filing a supplemental Biologics License Application for ADCETRIS in the AETHERA setting for the post-transplant consolidation treatment of Hodgkin lymphoma patients at high risk of relapse or progression. The FDA granted Priority Review for the application and the Prescription Drug User Fee Act target action date is August 18, 2015.
http://ift.tt/1E2OZD9

Drugs that activate brain stem cells may reverse multiple sclerosis

Two drugs already on the market - an antifungal and a steroid - may potentially take on new roles as treatments for multiple sclerosis. According to a study published in Nature today, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis.
http://ift.tt/1Ekq7bX

Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis

Scientists have identified two topical drugs capable of stimulating regeneration of damaged brain cells and reversing paralysis in animal models of MS. Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating around neurons that is damaged in diseases such as multiple sclerosis.
http://ift.tt/1yLve2D

Volunteer firefighter in health battle looking to hopeful future

Jon Moniz, one of Greenbrier's own, is down but with great hopes of rising back up so he can once again be of service to this community. Jon has been a Greenbrier Volunteer Fireman since 2009.
http://ift.tt/1cReSvk

A new lease on life for prostate tissue

Drugs that activate brain stem cells may reverse multiple sclerosis

Nervous Trading in Tokyo, Itochu Drops 11%

... 6,223 yen after Nikkei news reported pharmaceutical company plans to join hands with Kyoto University on stem cell research targeting treatments for heart disease and diabetes. Sources: Data collected by 123jump.com and Ticker.com from company press ...
http://ift.tt/1JZyZ5F

Drugs Stimulate Body's Own Stem Cells to Replace the Brain Cells Lost in Multiple Sclerosis

A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis. Led by researchers at Case Western Reserve, a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory.
http://ift.tt/1GcZbeq

Drugs that activate brain stem cells may reverse multiple sclerosis

IMAGE: This is an artist's representation of the study. Scientists found that certain drugs were able to promote remyelination in mouse models of multiple sclerosis.
http://ift.tt/1Oyym3C

Cellular Biomedicine Group Engages To Build Global KOL Advocacy For...

Cellular Biomedicine Group Inc. , a biomedicine firm engaged in the development of effective treatments for degenerative and cancerous diseases, today announced that the Company has engaged Huntsworth Health, a global healthcare marketing and communications agency to build a global KOL advocacy campaign for CBMG's ReJoinTM human adipose-derived mesenchymal progenitor cell clinical trials for the treatment of Knee Osteoarthritis.
http://ift.tt/1D7ey1N

Bionomics Limited Initiates Phase II Clinical Trial Of BNC210 For Treatment Of Anxiety

The study will use functional magnetic resonance imaging to assess the effects of BNC210 on brain activity in patients suffering from anxiety. "BNC210 has the potential to significantly improve the lives of anxiety sufferers, and we believe that with effective management of anxiety there is the potential to reduce the huge impact of the disease on societal and healthcare resources," said Dr. "Currently, there is a large unmet medical need for fast-acting anxiolytic agents that lack the side effects observed with existing treatments, which include sedation and addiction, as well as negative side effects on memory and body movement.
http://ift.tt/1D5Upbb

Drugs stimulate body's own stem cells to replace brain cells lost in multiple sclerosis

Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating around neurons that is damaged in diseases such as multiple sclerosis. Credit: Courtesy Case Western Reserve University; Illustrator: Megan Kern A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis.
http://ift.tt/1OyuoYB

University probes professor involved in stem-cell trial

THE University of Manitoba has launched an investigation into a Winnipeg physician involved in a controversial overseas stem-cell clinical trial. It's the fifth such investigation underway related to Regenetek, a Winnipeg-based company that charged roughly 70 multiple sclerosis and ALS patients from all over the world as much as $45,000 for stem-cell treatment at a hospital in India.
http://ift.tt/1E1LMDQ

Hemostemix to Present at the 2015 Annual Meeting of the Clinical Trials Association in Israel

Dr. Burchardt's presentation from 3:40-4:00 p.m. is entitled "Autologous Cell Therapy, Clinical Development of an Autologous Cell Therapy for Critical Limb Ischemia: Building on Past Successes and Lessons Learned." Hemostemix is the first clinical-stage biotech company to test a potential breakthrough stem-cell therapy in an international, multicenter, phase-2 clinical trial for patients with CLI, a severe form of peripheral artery disease caused by reduced blood flow to the legs.
http://ift.tt/1aKBDzr

New T cell-based immunotherapy shows promise for lethal stem cell transplant complication

More than 60 percent of patients with Epstein-Barr virus-associated lymphoproliferative disorder that was not responding to standard rituximab treatment responded to a new type of immunotherapy called Epstein-Barr virus-specific cytotoxic T lymphocyte therapy, according to data from two clinical trials presented at here the AACR Annual Meeting 2015, April 18-22. "One of the most concerning complications of blood stem cell transplantation, which has transformed the lives of many patients , including those with leukemia and lymphoma, is EBV-LPD," said Richard J. O'Reilly, MD, chairman of the Department of Pediatrics and chief of the Pediatric Bone Marrow Transplantation Service at Memorial Sloan Kettering Cancer Center in New York.
http://ift.tt/1OxUECC

Stem cells. Asymmetric apportioning of aged mitochondria between...

Science , Vol. 348, No. 6232. , pp. 340-343, doi:10.1126/science.1260384 To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document.
http://ift.tt/1E1cHzv

Scientists detect lymphoma relapse by monitoring cell-free tumor DNA

Circulating tumor DNA in the blood of patients treated for non-Hodgkin lymphoma can be used to identify those who are relapsing earlier, and with greater accuracy, than conventional monitoring, according to a study by researchers at the School of Medicine. The finding is important because it will allow clinicians to quickly identify patients who need additional treatment.
http://ift.tt/1DD08Je

Bionomics Initiates Phase II Clinical Trial of BNC210 for Treatment of Anxiety

Northampton fund-raiser takes on cycle challenge trip

Congratulations, you're now registered! Let us know what news and updates you want to hear about and we'll send them straight to your inbox. A fund-raiser from Northampton embarked on a remarkable cycle challenge over the Easter weekend to raise funds for a cancer charity.
http://ift.tt/1E0MbGm

Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal

... Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators ...
http://ift.tt/1E0Mbq1

New transitional stem cells discovered - may help advance research on pre-eclampsia

... likely resemble those encountered in the early stages of embryos. This should open the door for future stem cell research that is much more efficient. We now have new stem cells that are easier to manipulate since they are already at the key ...
http://ift.tt/1IwFv2I

Sunday, April 19, 2015

Acts 3:17-19. We Will Win

... because we are all God's children and he forgives us. All of us. He forgives those who perform embryonic stem cell research and create humans just to destroy them. He forgives those who perform abortions and those who aid in them. He forgives those ...

http://ift.tt/1P1DZte

A New Lease on Life for Prostate Tissue

New Brunswick, N.J., April 19, 2015 - What if a prostate cancer patient could learn which anti-cancer treatments would work best for him without having to swallow a single pill or endure a single intravenous line or injection? Research from Rutgers Cancer Institute of New Jersey involving the development of human organoid prostate models could have implications for how future therapy is guided for some of this population, say investigators. At focus is the development of prostate stem cell-derived organoids, the size of a pinhead, that were developed from prostate cancer biopsy and resected tissue taken from patients with early-stage and advanced prostate cancer.

http://ift.tt/1DA2A34

Is organ transplant wrong in the eyes of God?

... prestigious institute that we met and discussed a number of subjects, including abortion, euthanasia, stem cell research, homosexuality and organ transplant. Piccolo jokingly referred to himself as a "failed atheist" , after embracing secularism for ...

http://ift.tt/1G7OjP6

Saturday, April 18, 2015

Philanthropist, shopping mall developer Taubman dies at 91

Philanthropist Alfred Taubman, who changed the way Americans shop, dies at 91

... traveled to Hungary to figure out why the country's sausage was so good. He also became a major backer of stem cell research. But it was his rearrangement of how people shop -- parking lot in front, several stores in one stop close to home -- that ...

http://ift.tt/1IWOz41

Self-made Jewish billionaire and philanthropist Taubman dies at 91

A. Alfred Taubman, the self-made Michigan billionaire whose philanthropy and business success - including weaving the enclosed shopping mall into American culture - was clouded by a criminal conviction late in his career, has died. He was 91. Taubman, who donated hundreds of millions of dollars to universities, hospitals and museums, died Friday night at his home of a heart attack, according to son Robert S. Taubman, president and CEO of Taubman Centers, Inc. "This company and all that you stand for were among the greatest joys of his life," Robert S. Taubman wrote in a message to the company's employees.

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Michigan billionaire, shopping mall developer A. Alfred Taubman dies

A. Alfred Taubman, the self-made Michigan billionaire whose philanthropy and business success -- including weaving the enclosed shopping mall into American culture -- was clouded by a criminal conviction late in his career, has died. He was 91. Taubman, who donated hundreds of millions of dollars to universities, hospitals and museums, died Friday night at his home of a heart attack, according to son Robert S. Taubman, president and CEO of Taubman Centers, Inc. "This company and all that you stand for were among the greatest joys of his life," Robert S. Taubman wrote in a message to the company's employees.

http://ift.tt/1yEE6qB

Cell type responsible for scarring, skin-cancer growth identified by scientists

A skin cell responsible for scarring, and a molecule that inhibits the cell's activity, have been identified by researchers. The researchers also found that the cell may play a role in the growth of melanoma and in skin damage caused by radiation.

http://ift.tt/1zu14eX

Billionaire A Alfred Taubman dies

A Alfred Taubman, the self-made Michigan billionaire whose philanthropy and business success - including making the enclosed shopping mall part of American culture - was clouded by a criminal conviction late in his career, has died at the age of 91. Mr Taubman, who donated hundreds of millions of dollars to universities, hospitals and museums, died at his home of a heart attack, according to his son, Robert S Taubman, president and chief executive of Taubman Centers Inc. "This company and all that you stand for were among the greatest joys of his life," Robert S Taubman wrote in a message to the company's employees. "He was so proud of what this wonderful company he founded 65 years ago has accomplished."

http://ift.tt/1EWS48r

Philanthropist, shopping mall developer Taubman dies at 91

Bloomfield Hills, Mich. a A. Alfred Taubman, the self-made Michigan billionaire whose philanthropy and business success - including weaving the enclosed shopping mall into American culture - was clouded by a criminal conviction late in his career, has died.

http://ift.tt/1DkE4Qj

Next step for stem cell research

... in Zhang's research lab at the Waisman Center at the University of Wisconsin-Madison. The university is a stem cell research center and supplies many employees to Cellular Dynamics International. Pluripotent stem cells are maintained in dishes with ...

http://ift.tt/1G4wRIt

Philanthropist, shopping mall developer Taubman dies at 91

Experts probe use of stem cells to treat hockey legend Gordie Howe

... treatment. "I think it's an interesting case. I think it can have a huge impact on people's perception of stem cell research," says Dr. Duncan Stewart, the scientific director of Regenerative Medicine at the Ottawa Hospital Research Institute. "I ...

http://ift.tt/1HDzSBx?

Son: Michigan billionaire philanthropist, shopping mall developer A. Alfred Taubman dies

A. Alfred Taubman's 'epic American life' comes to a close

... maybe 15 years. I've lost track." Taubman gave millions of dollars directly to doctors who are doing stem cell research and trying to find cures for diseases, like ALS. "Because of Al Taubman, we now have new clinical trials in adult and pediatric ...

http://ift.tt/1Jfgd9j

A. Alfred Taubman: Shopping plaza billionaire, philanthropist, convicted criminal

Real estate mogul and Michigan billionaire A. Alfred Taubman is shown in his office in Bloomfield Hills, Mich., in this 2007 file photo. Taubman, whose business success and philanthropy was clouded by a criminal conviction late in his career, died Friday at his home.

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Great-grandfather of sprawl dies at 91

Shopping mall developer dies of heart attack at 91

Man with restored sight provides new insight into how vision develops

California man Mike May made international headlines in 2000 when his sight was restored by a pioneering stem cell procedure after 40 years of blindness. But a study published three years after the operation found that the then-49-year-old could see colors, motion and some simple two-dimensional shapes, but was incapable of more complex visual processing.

http://ift.tt/1CXqzqB

Philanthropist, shopping mall developer Taubman dies at 91

BLOOMFIELD HILLS, Mich. - A. Alfred Taubman, the self-made Michigan billionaire whose philanthropy and business success - including weaving the enclosed shopping mall into American culture - was clouded by a criminal conviction late in his career, has died.

http://ift.tt/1Je4oQJ

On TV

There's a full menu of hockey on the Saturday schedule, but the only one that really matters hereabouts is Game 2 of the Jets-Ducks series. And since it isn't a school night, everybody gets to stay up late to watch! Sportsnet, 9:30 p.m. Sarah searches for a kidnapped Helena while also dealing with a lethal investigator from a mysterious shadow corporation in this season premiere.

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Philanthropist, shopping mall developer Taubman dies at 91

Real estate mogul and Michigan billionaire A. Alfred Taubman is shown in his office in Bloomfield Hills, Mich., in this April 4, 2007 file photo. Taubman, whose business success and philanthropy was clouded by a criminal conviction late in his career, died Friday night April 17, 2015 at his home after a heart attack.

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Major University donor A. Alfred Taubman passes away

A. Alfred Taubman, one of the top donors in the University's history, passed away Friday night at age 91. His death was confirmed in a letter released by his son, Robert S. Taubman, to employees of Taubman Centers, Inc, according to the Detroit News. Robert S. Taubman is the current CEO of the company.

http://ift.tt/1Hinvdy

Project Manager II #1677

Will join the Stanley Center for Psychiatric Research at The Broad Institute to manage a portfolio of neuroscience projects, as well as be responsible for scientific manuscript and grant writing in the Neurobiology and Model Systems group. Will coordinate large, collaborative neuroscience research efforts and actively work to align these objectives with the overall scientific vision of the Stanley Center and its affiliated researchers.

http://ift.tt/1DSiIOY

Michigan Billionaire And Mall Developer A. Alfred Taubman Dies

Philanthropist, shopping mall developer Taubman dies at 91

The Miami Stem Cell Treatment Center Announces Adult Stem Cell Public Seminars in Sarasota, Florida

The Miami Stem Cell Treatment Center announces a series of free public seminars on the use of adult stem cells for various degenerative and inflammatory conditions. They will be provided by Dr. Thomas A. Gionis, Surgeon-in-Chief and Dr. Nia Smyrniotis, Medical Director.

http://ift.tt/1CXhGx4

Philanthropist, shopping mall developer Taubman dies at 91

Friday, April 17, 2015

Synergistic and antagonistic interplay between myostatin gene...

Synergistic and antagonistic interplay between myostatin gene expression and physical activity levels on gene expression patterns in triceps Brachii muscles of C57/BL6 mice. Levels of myostatin expression and physical activity have both been associated with transcriptome dysregulation and skeletal muscle hypertrophy.

http://ift.tt/1ETMFik

One Diabetes Drug Could Mean The End Of Scars

Harrison Undergraduate Awards allow students to expand research

The Harrison Undergraduate Research Awards provides up to $3,000 in grants for students to perform research over the summer. Each recipient of the Harrison Award works with a University faculty mentor and graduate students who aid the student's research in their respective areas of interest.

http://ift.tt/1PZBf0V

Diabetes Drug Could Prevent Scarring Through Targeting Fibroblasts

Scientists have long wondered the necessity of scars to the body's healing process; when we are injured, why can't our skin just regenerate back to the way it looked previously? Why do we have to carry such an unsightly reminder of the past, sometimes in visible places we don't want others to see? While some may see scars as the symbol of the healing process, others see them as a cosmetic burden. Does our body need scars to heal , or can we do without them without risks of infections or wounds reopening? Dr. Michael Longaker, co-director of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University, sought to uncover the mystery behind scars, and whether they are necessary.

http://ift.tt/1DghLLy

Erythroid differentiation in chimaeric mice blocked by a targeted...

The zinc-finger transcription factor GATA-1 murine embryonic stem cell line and tested the GATA-1-deficient cells for their ability to contribute to different tissues in chimaeric mice. The mutant embryonic stem cells contributed to all non-haemopoietic tissues tested and to a white blood cell fraction, but failed to give rise to mature red blood cells.

http://ift.tt/1ET2Mgh

Cell Type Responsible for Scarring, Skin-cancer Growth Identified

A skin cell responsible for scarring, and a molecule that inhibits the cell's activity, have been identified by researchers at the Stanford University School of Medicine. The molecule slowed wound healing in mice but alleviated scarring, the researchers said.

http://ift.tt/1OnMLj5

Only chance at MS treatment a $200k trip

Hamish Bockett-Smith has loaded his mortgage to afford the $200,000 treatment for MS which is only available in New Zealand for cancer patients. Photo / Mark Mitchell Hamish Bockett-Smith is about to spend 12 weeks in Singapore undergoing a gruelling stem cell transplant procedure in an attempt to halt the steady destruction multiple sclerosis is inflicting on his body.

http://ift.tt/1zpFIiR

Cellular Biomedicine Group To Present At In London, UK

Cellular Biomedicine Group Inc. , a biomedicine firm engaged in the development of effective treatments for degenerative and cancerous diseases, today announced that management has been invited to present at the 10th Annual World Stem Cells & Regenerative Medicine Congress to be held at the Business Design Centre in London, UK on May 20-22, 2015. Dr. William Cao, Chief Executive Officer, will present clinical update on the Company's Chimeric Antigen Receptor T cell programs on May 21, 2015 at 2:50pm during the segment titled "Spotlight On T-Cells".

http://ift.tt/1DeoKot

Genmab A/S Achieves USD 10 Million Milestone In Daratumumab Collaboration With Janssen Biotech Inc.

Genmab A/S announced today it has reached the fifth milestone in its daratumumab collaboration with Janssen Biotech, Inc. . The USD 10 million milestone payment was triggered by progress in the ongoing Phase III study which compares daratumumab in combination with bortezomib, melphalan and prednisone to bortezomib, melphalan and prednisone alone as front line treatment for patients who are not considered candidates for stem cell transplantation .

http://ift.tt/1OOh1pf

Full-Service Cro Cti - Clinical Trial and Consulting Services...

April 15, 2015 - Medidata , the leading global provider of cloud-based solutions for clinical research in life sciences, today announced that CTI Clinical Trial and Consulting Services , a therapeutically-focused, full-service contract research organization , is expanding its use of the Medidata Clinical CloudA platform to improve operational efficiencies, data accessibility and decision-making processes for its clinical trials. "We're excited to continue building our partnership with Medidata," said Kevin Schwarz, CTI's chief operating officer.

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Zebrafish research tests safer, less toxic cancer therapies

Dalhousie Medical School researchers have successfully been able transplant human leukemia cells into zebrafish embryos to study their growth and test anti-cancer therapies. Credit: Nick Pearce photo Two new cancer studies out of Dalhousie Medical School have shown success in testing safer, less toxic treatments for a rare form of pediatric leukemia called T-cell acute lymphocytic leukemia .

http://ift.tt/1OmSN3g

Van Gogh's left ear, cloned for science and art

This is Van Gogh's left ear. The one he famously chopped off. Kind of. Artist Diemut Strebe worked with stem cell scientists -- including the creator of the controversial " ear mouse " -- to grow the cartilage over the period of a year in a bioreactor, using tissue donated by a living relative of the tortured Dutch painter.

http://ift.tt/1ImoMz3

Novogen Limited And Feinstein Institute Join Forces To Find Effective Treatments For Brain Cancer

At the heart of the collaboration is the Company's super-benzopyran drug technology platform, distinguished by its ability to kill the full spectrum of cells within a tumor including both rapidly- and slowly-dividing cancer cells .

http://ift.tt/1CWgAjS

Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer

Australian drug discovery company, Novogen, today announced that it had signed a Memorandum of Understanding with the Feinstein Institute for Medical Research of New York to collaborate with the objective of developing effective treatments for brain cancers. The collaboration brings together the drug discovery expertise of Novogen and the preclinical and clinical expertise of the Feinstein Institute in neurosciences and oncology.

http://ift.tt/1cCm3aF

Osiris Therapeutics Announces First Quarter 2015 Financial Results Conference Call

... in biotechnology by focusing on innovation in regenerative medicine - including bioengineering, stem cell research and viable tissue based products. Osiris has achieved commercial success with products in orthopaedics, sports medicine and wound ...

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Panther Biotechnology Announces New Drug Candidate to Selectively Kill Leukemia Stem Cells

Under the terms of the agreement, Panther has licensed from the University of Rochester, the rights to develop and commercialize a first in class new chemical entity with demonstrated powerful anti-leukemia activity. The licensed compound, called TDZD-8, is a small molecule engineered to kill leukemic stem cells.

http://ift.tt/1cCm1iU

Solicore, CareSync, Lung Institute among top venture capital deals

Three Tampa Bay area firms were among the largest recipients of venture capital funding in Florida in the first quarter of 2015. The investments in Solicore Inc., CareSync Medical Group LLC and Lung Institute LLC came during a quarter when overall venture funding dipped slightly, according to the MoneyTree Report from PricewaterhouseCoopers and the National Venture Capital Association , based on data provided by ThomsonReuters.

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Gordon K. Klintworth Exposes Giants, Crooks and Jerks in Science

Over the years, scientific frauds have made its way to international headlines; from the Piltdown man hoax of the 20th century to more recent scandals like Hwang Woo-suk's infamous stem cell research. The late Gordon K. Klintworth 's extensive career in the field of science and in the academe has exposed him to a number of questionable scientific practices, particularly in the area of research.

http://ift.tt/1OMIN5C

Gordie Howe, NHL legend, makes gritty fight back from stroke

In this March 1, 2013, file photo, Hall of Fame hockey player Gordie Howe, center, is joined by, from left, Marcel Dionne, Johnny Bower, Canadian singer Michael Buble and Jim Robson during an 85th birthday ceremony for Howe before the Vancouver Giants and Lethbridge Hurricanes WHL hockey game in Vancouver, British Columbia. An experimental stem cell treatment in Mexico late last year brought a life changing turnaround that s put the 87-year-old back Howe back on his feet after a significant stroke robbed him of the ability to walk and talk normally.

http://ift.tt/1PX5e9K

Donors rush to register to help Brierley Hill teen in need of bone marrow transplant

THE plight of a Brierley Hill teenager in a race against time for a bone marrow transplant touched so many hearts that the number of people from the area stepping forward to be donors has soared. Leukaemia sufferer Omar Al-Shaikh's only hope for life is to find a suitable person from his mixed heritage background with matching bone marrow to donate their stem cells for transplant.

http://ift.tt/1NWbShR

BioRestorative Therapies, Inc. Announces Opening Of New Headquarters...

BioRestorative Therapies, Inc. , a life sciences company focused on adult stem cell-based therapies for various personal medical applications, announced today that the Company has relocated its corporate, administrative and laboratory operations to Melville, Long Island, New York. The Company had previously announced a relocation incentive program offered by New York State and Suffolk County that helped enable BRT to establish a new facility in New York for its corporate headquarters and cell biology laboratory.

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Guide To Organoid Growth Launched

AMSBIO has launched, at the 'Frontiers in Stem Cells & Cancer' EMBL-EMBO Symposium, a guide that illustrates a variety of organoids grown from different tissues by leading international research groups using BME 2 reduced growth factor extracellular matrix that is available from the company. Organoids are organ-like structures that can be formed by 3D cell culture and differentiation of stem cells or organ progenitors.

http://ift.tt/1OLSVM2

Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative...

Global Stem Cells Group will attend the world-class GTCbio conference at the Hyatt Regency Boston Hotel, April 27-29. The event will showcase the latest developments in all areas of regenerative medicine, stem cell research and business.

http://ift.tt/1OLsS7E

Gordon K. Klintworth Exposes 'Giants, Crooks and Jerks in Science'

Steering the epigenome to turn specific genes on

Duke University researchers have developed a new method to precisely control when genes are turned on and active: by manipulating the epigenome - the web of proteins that supports and controls gene activity and a current hot topic in cancer research. The researchers say having the ability to steer the epigenome will help them explore the roles that particular promoters and enhancers play in cell fate or the risk for genetic disease, and it could provide a new avenue for gene therapies and guiding stem cell differentiation.

http://ift.tt/1G2scJT

Thursday, April 16, 2015

U-M Health System Launches $160M Project to Improve Lab Tests for Patients

ANN ARBOR, Mich. - Millions of times a year, teams at the University of Michigan Health System test samples of tissue, blood and other bodily fluids for patients of all ages.

http://ift.tt/1b8rrC2

Letters: Final indignity: No help for poor to pay burials

Under Gov. Bruce Rauner, the state no longer will pay burial costs for the indigent. Photo by Joseph P. Meier, Sun-Times More than 50 years ago, a Boston attorney named Joseph N. Welch stopped Sen. Joseph McCarthy in his tracks with the words: "Have you no sense of decency, sir?" It is time to ask Gov. Bruce Rauner the same question.

http://ift.tt/1Okkwl7

Will scars become a thing of the past? Stanford scientists identify cellular culprit

I have a scar on my chin from a fall I took while rollerskating when I was about 12. One minute I was blithely zooming along to Bob Seger's hit Against the Wind , reveling in my new ability to skillfully cross one foot in front of the other and thinking about that cute boy by the snack counter, and the next I was chin down skidding across the flat, grey and very hard floor to come to rest against the wooden wall in an ignominious heap. Although the experience left an impression on my psyche, as well as my skin, I can't claim any long-lasting problem from the thin line on my chin.

http://ift.tt/1FPAXkQ

"You just get lifted away from the earth": Film spotlights dance...

Tomorrow and Saturday, "Capturing Grace," a documentary film following participants of a dance program for people with Parkinson's disease generated by New York's Mark Morris Dance Group , will be screened at Stanford. Filmmaker and former KQED Forum host Dave Iverson, and David Leventhal, previously a leading dancer of MMDG and now the director of Dance for PD , will also be on campus holding workshops and discussions.

http://ift.tt/1yxsiWY

UCI receives $11 million grant to continue ground-breaking Alzheimer's research

... to make sure there is funding available for this type of critical research." McAleer said the type of stem cell research the institute is doing "lowers the volume" on ethical concerns relating to embryonic stem cells, propelling studies further. ...

http://ift.tt/1JNN5H2

Dance Division brings documentary about dancing with Parkinson's to campus

David Leventhal, director of Dance for PD, teaches a community class. Stanford's Dance Division, Dance for PD and the Mark Morris Dance Group are presenting a film about dance and Parkinson's disease on campus Friday and Saturday.

http://ift.tt/1Ojxjo2

Paul: GOP should hit Democrats on abortion

... Obama's broken promise to prohibit abortion funding in Obamacare, and the abject failure of embryonic stem cell research. "Never assume they are telling the truth," Smith said. "Nine times out of 10 it's either a big fat lie or it's a half truth, ...

http://ift.tt/1NSwNCq

The ALS Association, Harvard Stem Cell Institute, And Collaborate...

In parallel testing, brain cells will be made from each patient's stem cells to see if they can predict which patients might respond to the medicine. The trial will evaluate the potential of the drug, Retigabine, which has a unique mechanism of action and can calm the excitability of nerve cells that are thought to cause seizures.

http://ift.tt/1PTF9rZ

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