E-mail: m.vinciguerra@operapadrepio.it Received 19 March 2014; Revised 6 May 2014; Accepted 15 May 2014 Accepted article preview online 21 May 2014; Advance online publication 17 June 2014 In the context of obesity, epigenetic mechanisms regulate cell-specific chromatin plasticity, perpetuating gene expression responses to nutrient excess. MacroH2A1, a variant of histone H2A, emerged as a key chromatin regulator sensing small nutrients during cell proliferation and differentiation.
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