Optimized Generation of Functional Neutrophils and Macrophages from Patient-Specific Induced Pluripotent Stem Cells: Ex Vivo Models of X -Linked, AR22 - and AR47 - Chronic Granulomatous Diseases. Chronic granulomatous disease is an inherited orphan disorder caused by mutations in one of the five genes encoding reduced oxidase subunits, which subsequently lead to impairment in the production of microbicidal reactive oxygen species .
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http://ift.tt/1z1u6AY
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