Sequence of Genetic Mutations Determines How Cancer Behaves

Most of the genetic mutations that cause cancer result from environmental 'damage' or from spontaneous errors as cells divide. In a study published today, researchers at the Department of Haematology, the Cambridge Institute for Medical Research and the Wellcome Trust/Medical Research Council Stem Cell Institute show for the first time that the order in which such mutations occur can have an impact on disease severity and response to therapy.

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