Cell Death and Differentiation 22, 540–548; doi:10.1038/cdd.2014.239; published online 23 January 2015 Correspondence: E Gallagher, Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK, Tel: +44 7947 778996; Fax: +44 2075 640814; E-mail: ewen.gallagher@ntlworld.com or t.suddason@imperial.ac.uk Despite the sizable number of components that comprise Mapk cascades, Map3k1 is the only element that contains both a kinase domain and a plant homeodomain motif, allowing Map3k1 to regulate the protein phosphorylation and ubiquitin proteasome systems. As such, Map3k1 has complex roles in the regulation of cell death, survival, migration and differentiation.
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