Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation

Correspondence: Dr C Zaph, The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, Canada V6T1Z3. E-mail: colby.zaph@monash.edu Repressive epigenetic modifications such as dimethylation and trimethylation histone H3 at lysine 9 and H3K27me3 have been shown to be critical for embryonic stem cell differentiation by silencing cell lineage-promiscuous genes.

http://ift.tt/1EYSvjb