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Wednesday, March 25, 2015

Significant blocking of opioid tolerance with mesenchymal stem cell transplant

Mesenchymal stem cell transplantation reduced opioid tolerance and opioid-induced hyperalgesia caused by daily morphine injections in rats, according to new research. Not only was opioid tolerance prevented when the rats were transplanted with MSC before repeated morphine injections, but tolerance was reversed when the rats were treated after opioid tolerance had developed, results demonstrated.

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