Twin copies of gene pair up in embryonic stem cells at critical moment in differentiation

Both copies of the Oct4 gene physically come together just as embryonic stem cells begin to develop into tissue-specific cell types We and other mammals have two copies of each gene, and each copy, or 'allele,' was thought to remain physically apart from the other in the cell nucleus. David Spector's team now finds that the alleles of a specific gene, Oct4, can and do pair up in mammalian cells.

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