Stem Cell Roundup: February 2015

Saturday, February 28, 2015

Graphene Shows Promise In Eradication Of Stem Cancer Cells

Having once been called the tech Hemingway of Paris, named one of the top 100 women in technology in Europe in 2012, short-listed for best tech journalist by the TechCrunch Europas, I like to fix problems with my own special brand of strategy, storytelling and writing. As a former assistant press secretary to a US Senator, DOE spokesperson, frequent speaker and host of a few of Europe's leading tech and mobile conferences, I've been on all sides of story telling, comms in all its forms.

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Cat Zingano's Road to Recovery

It was a routine training exercise. A maneuver Cat Zingano - the #3 ranked Women's UFC fighter - had effortlessly executed hundreds of times.

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Strategy to Save Northern White Rhino

With support from the Seaver Institute, geneticists at San Diego Zoo Institute for Conservation Research are taking the initial steps in an effort to use cryopreserved cells to bring back the northern white rhino from the brink of extinction. Living cells banked in the Frozen ZooA have preserved the genetic lineage of 12 northern white rhinos, including a male that recently passed away at the Safari Park.

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Good Sleep Keeps Your Stem Cells Young

Under normal conditions, many of the different types of tissue-specific adult stem cells, including hematopoietic stem cells, exist in a state or dormancy where they rarely divide and have very low energy demands. "Our theory was that this state of dormancy protected hematopoietic stem cells from DNA damage and therefore protects them from premature aging," says Dr. Michael Milsom, leader of the study.

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Loran Smith: UGA scientists working on animal extinction issues

... The Masters with a double-eagle finish. Stice cloned a cow several years ago. He foresees the day when stem cell research may be able to cure Parkinson's disease, or enable victims of paralysis to be rehabilitated. His multiple interests make him ...

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New Market Research Report: Sickle-cell Anemia Therapeutics Market in the US 2015-2019

While normal erythrocytes have a life span of 120 days, sickle-shaped erythrocytes die within 10 to 20 days. The bone marrow is unable to compensate for the excessive loss of erythrocytes, thereby leading to anemia.

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Stigma for cancer patients too

Cancer just like many terminal illnesses is thought to hit its victims hardest when they do not have a strong emotional support system. As a result, social support has been identified as an important factor if any patient battling cancer ever has a chance at beating it.

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Three-Parent IVF: What's The Hurry?

... moving far too aggressively ahead with this new treatment before all the science is settled. U.C. Davis stem cell research scientist Paul Knoepfler provides a quick review of some of these, including the potential for cancer, and a recent paper by ...

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Photo Illustration by Emil Lendof/The Daily Beast

An Italian doctor says head transplants could be possible in the next two years. But just because we can, does that mean we should? Please allow me to introduce the opening scene of a science fiction film to you.

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Culture conditions in which stem cells are grown can affect genetic stability

The therapeutic promise of human stem cells is indisputably huge, but the process of translating their potential into effective, real-world treatments involves deciphering and resolving a host of daunting complexities. Writing in the February 25 online issue of the journal PLOS ONE , researchers at University of California, San Diego School of Medicine, with collaborators from The Scripps Research Institute , have definitively shown for the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.

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CLL patients discontinue ibrutinib drug due to disease progression during clinical trials

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online in JAMA Oncology . CLL is the most prevalent leukemia in adults and it is not considered curable without an allogeneic stem cell transplant.

http://ift.tt/1BMjm1b

Novel financing technique may unlock funding for developing 'orphan' drugs to treat rare diseases

A paper published today, "Financing translation: Analysis of the NCATS rare-diseases portfolio" in Science Translational Medicine, demonstrates the potential of a new financing technique to reduce the risk associated with investing in the treatment of new diseases and potentially unlock new levels of funding for developing so-called "orphan" drugs.

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Findings reveal variations between countries and regions in use of HSCT procedure

Since the first experimental bone marrow transplant over 50 years ago, more than one million hematopoietic stem cell transplantations have been performed in 75 countries, according to new research charting the remarkable growth in the worldwide use of HSCT, published in The Lancet Haematology journal. However, the findings reveal striking variations between countries and regions in the use of this lifesaving procedure and high unmet need due to a chronic shortage of resources and donors that is putting lives at risk.

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Miracle cure?

Diagnosed with Lewy Body Dementia in 2007 the disease began to strip away the person he was. Over the next seven years his vibrant and active life spent golfing, bowling and travelling was ravaged.

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New strategy may ensure safety of adult epidermal stem cells before performing treatments

A team of European researchers has devised a strategy to ensure that adult epidermal stem cells are safe before they are used as treatments for patients. The approach involves a clonal strategy where stem cells are collected and cultivated, genetically modified and single cells isolated before being rigorously tested to make sure they meet the highest possible safety criteria.

http://ift.tt/1Dkvdi3

Researchers successfully convert adult human skin cells into neurons that control appetite

Researchers have for the first time successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight control and testing new therapies for obesity. The study, led by researchers at Columbia University Medical Center and at the New York Stem Cell Foundation , was published last month in the online issue of the Journal of Clinical Investigation .

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In memory, the Slye family has a movement: paying forward

The Slye family could have walled themselves off Friday, grieved privately, curled up under the covers because the pain is fresh. Exactly one year ago, A.J., the older brother of Virginia Tech freshman kicker Joey Slye and the son of David and Laura, died at age 20 at St. Jude's Children's Research Hospital in Memphis, Tenn.

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Friday, February 27, 2015

Reasons for ibrutinib therapy discontinuation in patients with chronic lymphocytic leukemia

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology. About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology .

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MicroRNA-26a induced by hypoxia targets HDAC6 in myogenic differentiation of embryonic stem cells

The importance of epigenetic regulation for maintenance of embryonic stem cell pluripotency or for initiation of differentiation is widely accepted. However, the molecular mechanisms are poorly understood.

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Reasons for ibrutinib therapy discontinuation in patients with chronic lymphocytic leukemia

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology. About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology .

http://ift.tt/1ayMH33

Reasons for ibrutinib therapy discontinuation in CLL

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a new study. About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online in JAMA Oncology .

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Associate / Full Professor Level to Fill a Tenured Position

Upstate Medical University seeks a neuroscientist at the Associate/Full Professor level to fill a tenured position as part of the New York State Empire Innovator Program, which aims to expand the ranks of world-class faculty in the system. Research should focus on studying the mechanisms of neurological function, disease, and dysfunction at the cellular, molecular or systems levels.

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Researchers detail reasons for ibrutinib therapy discontinuation in CLL

Stem cells may save lives, dentist says

John W. Vollenweider, a general practice dentist, tends to patient Blake Lowry at his office in August 2014.

http://ift.tt/1LMCYn8

Myelin-maker: How an FDA-approved drug boosts myelin synthesis

The brainstem of a myelin-deficient mouse that received a transplant of human OPCs a few days after birth and was then treated with the drug solifenacin. Daily treatment enhanced the capacity of human cells to produce myelin , which led to improved hearing in the mouse.

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Adult Stem Cell Transplants Reach 1 Million Worldwide - And Are Still Underused

It's been over 50 years since the first experimental use of adult stem cells - bone marrow transplants - began, and in that time over 1,000,000 hematopoietic stem cell transplantations or from a healthy donor to replace those lost to disease or chemotherapy. Using data collected by the Worldwide Network for Blood and Marrow Transplantation , Professor Dietger Niederwieser from the University Hospital Leipzig in Germany and international colleagues, systematically analysed the growth of HSCT and changes in its use in 194 WHO member countries since the first transplant in 1957.

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Mystery of the reverse-wired eyeball solved

From a practical standpoint, the wiring of the human eye - a product of our evolutionary baggage - doesn't make a lot of sense. In vertebrates, photoreceptors are located behind the neurons in the back of the eye - resulting in light scattering by the nervous fibers and blurring of our vision.

http://ift.tt/1wrIjas

Neurons controlling appetite made from skin cells

... ll Foundation (NYSCF) - a non-profit organization dedicated to advancing cures for major diseases through stem cell research - today applauded the announcement by

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'Big brain' gene found in humans, not chimps

New research suggests that a single gene may be responsible for the large number of neurons found uniquely in the human brain. When this gene was inserted in the brain of a mouse embryo , it induced the formation of many more neuron A single gene may have paved the way for the rise of human intelligence by dramatically increasing the number of brain cells found in a key brain region.

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Mayo Clinic Study Shows Stem Cells Have Potential To Help Kids' Hearts, Too

... significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices. ...

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PTC Therapeutics Reports Fourth Quarter And 2014 Full Year Financial...

We are now a growing commercial-stage biopharma company, focused on delivering and developing RNA-targeted therapies in the rare disease space," stated , Ph.D., Chief Executive Officer, PTC Therapeutics, Inc. "We are proud to bring the first treatment for Duchenne muscular dystrophy to patients who suffer from this devastating disorder. Concurrent with our ongoing launch activities in and around the world, we are beginning to build out our commercial infrastructure in the US in preparation for a potential launch in 2016.

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Bionomics Limited Release: New BNC105 Biomarker Data To Be Presented At

Elevated baseline Ferritin and lower baseline IL-8 were associated with improved PFS . Eighty nine percent of patients expressing elevated plasma levels of Ferritin and lower plasma levels of IL8 at baseline were disease progression free at 6 months.

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Neurons controlling appetite made from skin cells

... ll Foundation (NYSCF) - a non-profit organization dedicated to advancing cures for major diseases through stem cell research - today applauded the announcement by

http://ift.tt/1wrIhj4

New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases

A paper published today, " Financing translation: Analysis of the NCATS rare-diseases portfolio " in Science Translational Medicine, demonstrates the potential of a new financing technique to reduce the risk associated with investing in the treatment of new diseases and potentially unlock new levels of funding for developing so-called "orphan" drugs.

http://ift.tt/1wrDGgL

Terrorist attacks have shifted from air to rail, study suggests

Data on terrorist attacks from 1982 to 2011 show a long-term trend away from air attacks and toward railroad and subway attacks, underscoring the need for increased intelligence gathering to intercept those redirected attempts. Successful terrorists have shifted their focus in recent years away from attacking airlines to attacking subway and rail systems, according to an analysis of terrorist attacks over a 30-year period from 1982 to 2011 by a leading health and safety researcher.

http://ift.tt/1wrDG0m

Neurons controlling appetite made from skin cells

Researchers have for the first time successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight control and testing new therapies for obesity. Columbia researchers have developed a method to generate hypothalamic-like neurons from human pluripotent stem cells.

http://ift.tt/1ABperF

New approach to assessing effectiveness of anti-cancer drugs

Scientists have a developed a new method to monitor the effect of anti-cancer drugs on very rare leukemia stem cells. The approach potentially allows doctors to screen patients and personalize their treatment.

http://ift.tt/1ABperB

"Big Brain" Gene Allowed for Evolutionary Expansion of Our Neocortex

Hiv controls its activity independent of host cells

A major hurdle to curing people of HIV infection is the way the virus hides in a reservoir composed primarily of dormant immune cells. It is generally believed that HIV does not replicate in these cells because the virus depends on active cellular machinery to do so.

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Experts warn of stem cell underuse as transplants reach one million worldwide

Findings of a new reveal striking variations between countries and regions in the use of this lifesaving stem cell transplantation, and high unmet need due to a chronic shortage of resources and donors that is putting lives at risk, experts report. However, the findings reveal striking variations between countries and regions in the use of this lifesaving procedure and high unmet need due to a chronic shortage of resources and donors that is putting lives at risk.

http://ift.tt/1868e1a

New approach to assessing effectiveness of anti-cancer drugs

Amelotin molecule plays critical role in tooth enamel maturation

An innovative developmental biology study relates amelotin with tooth enamel defects and enamel formation. "This is a significant study because it is the first report of a basement membrane protein playing a role in enamel mineralization," said one researcher.

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New approach to assessing effectiveness of anti-cancer drugs

Quality control for adult stem cell treatment

Researchers develop quick test for fish toxin

Using a credit card-sized device called a microfluidic chip, the researchers have developed a way to test for histamine - a potentially toxic compound - without the need to use complex chemical additives to the fish. Histamine is a naturally occurring organic compound found in a range of products, including fish and red wine.

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Breakthrough in understanding how cancer cells metastasize

A protein commonly found in human cells could be an important switch that activates cancer cell metastasis, according to a new study. The finding focuses attention on a biological mechanism that until now was largely overlooked.

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Newly-Found T Memory Stem Cells May Be Key to Gene Therapy

Genetically engineered T memory stem cells can last more than 12 years in patients' bodies, and can continually generate appropriate T cell armies for them, says an innovative study looking at two historic clinical trials. It was known that mature human memory T cells could persist-if no one knew for how long.

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Neurons Controlling Appetite Made From Skin Cells

Capricor Therapeutics, Inc. Appoints As Vice President Of Regulatory Affairs And Drug Development

Capricor Therapeutics, Inc. , a biotechnology company focused on developing novel therapeutics for the treatment of cardiovascular diseases, today announced that Thomas Copmann, Ph.D., has been appointed to the newly created position of Vice President of Regulatory Affairs and Drug Development. In this role, Dr. Copmann will lead the company's regulatory initiatives and strategy, ensure appropriate regulatory compliance in the conduct of all Capricor development programs and manage reporting to the FDA and health authorities.

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Moffitt Cancer Center Researchers Identify Protein Pathway Involved in Brain Tumor Stem Cell Growth

TAMPA, Fla. - Glioblastomas are a highly aggressive type of brain tumor, with few effective treatment options.

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Quality control for adult stem cell treatment

Three New SC Ethics Complaints Set To Be Filed

New ethics complaints against three state lawmakers are in the final stages of being filed, sources familiar with the documents tell FITS. Complaints will be reportedly be filed against S.C. Reps.

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PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial...

PTC Therapeutics, Inc. today announced a corporate update and reported financial results for the fourth quarter and full year ended December 31, 2014. "2014 was a transformative year for PTC.

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New BNC105 Biomarker Data to be Presented at US Cancer Conference

Bionomics Limited is to present important additional data from the DisrupTOR-1 trial of BNC105 in patients with metastatic renal cancer at the ASCO Genitourinary Cancers Symposium in Orlando, Florida. The data will be presented by Dr. Sumanta Pal of the City of Hope Comprehensive Cancer Center in California in his poster presentation.

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A gene for brain size only found in humans

This picture shows a cerebral cortex of an embryonic mouse. The cell nuclei are marked in blue and the deep-layer neurons in red.

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Global Cell Culture Protein Surface Coating Industry: Rising Focus...

... the global cell culture protein surface coating industry is increased focus of top market players towards stem cell research. However, the drawbacks of animal-derived protein surface coating is a factor that is soon becoming a matter of concern, ...

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Reasons for ibrutinib therapy discontinuation in patients with chronic lymphocytic leukemia

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology . CLL is the most prevalent leukemia in adults and it is not considered curable without an allogeneic stem cell transplant.

http://ift.tt/1FDIq7L

Life-saving bone marrow transplants are not available to all who need them

New research published in The Lancet Haematology reports that despite huge increases in the use of bone marrow transplant, there is significant underuse in various regions across the world. The high level of unmet need is a consequence of chronic shortages of resources and donors and is putting lives at risk.

http://ift.tt/1LQOfmn

Culture clash: How stem cells are grown affects their genetic stability

New approach to assessing effectiveness of anti-cancer drugs

Manchester scientists have a developed a new method to monitor the effect of anti-cancer drugs on very rare leukaemia stem cells. The approach potentially allows doctors to screen patients and personalise their treatment.

http://ift.tt/1woV5Xg

Experts warn of stem cell underuse

Multiple facets of histone variant H2AX: a DNA double-strand-break...

In the last decade, many papers highlighted that the histone variant H2AX and its phosphorylation on Ser 139 cannot be simply considered a specific DNA double-strand-break marker with a role restricted to the DNA damage response, but rather as a 'protagonist' in different scenarios. This review will present and discuss an up-to-date view regarding the 'non-canonical' H2AX roles, focusing in particular on possible functional and structural parts in contexts different from the canonical DNA DSB response.

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New approach to assessing effectiveness of anti-cancer drugs

Designer Superbabies Could Rewrite Human Reproduction

Lydia Kang is an author of young adult fiction, poetry, and narrative non-fiction. Her debut novel, " Control " and its sequel, " Catalyst " are published by Penguin/Kathy Dawson Books.

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Thursday, February 26, 2015

Ocata Therapeutics To Trade On Nasdaq Global Market: Can The Bulls Finally Rejoice?

After months, if not years for some, Ocata shareholders were pleasantly surprised by the after-hours filing of the Form 8-A on February 23, 2015 by Ocata Therapeutics , which provides for registration of certain classes of securities pursuant to Section 12 or of the Securities Exchange Act of 1934. The filing indicates that trading shall commence on February 26, 2015, and that shares will be listed on the Nasdaq Global Market under the current ticker symbol, OCAT.

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Researchers one step closer to understanding development of glioblastoma

Glioblastomas are a highly aggressive type of brain tumor, with few effective treatment options. Moffitt Cancer Center researchers are one step closer to understanding glioblastoma development following the identification of a key protein signaling pathway involved in brain tumor stem cell growth and survival.

http://ift.tt/1Ae4UHS

The Lancet Haematology: Experts warn of stem cell underuse

Strategy to Save Northern White Rhino is Launched New Genetic Technologies Offer Hope for Species

The Irvine Stem Cell Treatment Center Announces Adult Stem Cell...

Upcoming Adult Stem Cell Lectures: Riverside - Saturday, March 7; Ontario - Tuesday, March 10; and Brea, California - Saturday, March 21, 2015. The Irvine Stem Cell Treatment Center announces a series of free public seminars on the use of adult stem cells for various degenerative and inflammatory conditions.

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Xeroxed gene may have paved the way for large human brain

Last week, researchers expanded the size of the mouse brain by giving rodents a piece of human DNA. Now another team has topped that feat, pinpointing a human gene that not only grows the mouse brain but also gives it the distinctive folds found in primate brains.

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Vical Incorporated Reports Fourth Quarter 2014 Financial Results And...

Vical Incorporated today reported financial results for the three months and twelve months ended December 31, 2014. Net loss for the fourth quarter of 2014 was $4.6 million, or $0.05 per share, compared with a net loss of $2.2 million, or $0.03 per share, for the fourth quarter of 2013.

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Graphene shown to neutralize cancer stem cells

University of Manchester scientists have used graphene oxide to target and neutralize cancer stem cells while not harming other cells. This new development opens up the possibility of preventing or treating a broad range of cancers, using a non-toxic material.

http://ift.tt/1LNVnQz

'Big Brain' Gene Found in Humans, Not Chimps

Same-sex couples may one day have biological children, researchers say

ABC News A stem cell research breakthrough might someday allow same-sex couples to have their own biological children. Researchers at Cambridge University in England have taken the first steps towards creating artificial sperm and eggs by reprogramming skin cells from adults and converting them into embryonic-like stem cells.

http://ift.tt/1LNQ0AT

Strategy to Save Northern White Rhino Is Launched; New Genetic Technologies Offer Hope for Species

[Report] CTCF establishes discrete functional chromatin domains at...

Hox genes confer positional identity to cells and tissues. Maintaining precise spatial patterns of Hox gene expression is vital during metazoan development.

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Small molecule helps get stem cells to sites of disease, damage

Bioengineers from Brigham and Women's Hospital with collaborators at the pharmaceutical company Sanofi have identified small molecules that can be used to program stem cells to home in on sites of damage, disease and inflammation. The techniques used to find and test these small molecules may represent important tools in advancing cell-based therapy, offering a new strategy for delivering cells to the right locations in the body.

http://ift.tt/18qsko6

Study affirms role of specialized protein in assuring normal cell development

Scientists at NYU Langone Medical Center and New York University have demonstrated that a specialized DNA-binding protein called CTCF is essential for the precise expression of genes that control the body plan of a developing embryo. The findings, to publish online February 27 in Science , focus on mouse brain cells that work to manage an animal's movements.

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Small molecule helps get stem cells to sites of disease and damage

Researchers identified a small molecule that can be used to program mesenchymal stem cells to home in on sites of damage. Credit: Oren Levy, Brigham and Women's Hospital Bioengineers from Brigham and Women's Hospital with collaborators at the pharmaceutical company Sanofi have identified small molecules that can be used to program stem cells to home in on sites of damage, disease and inflammation.

http://ift.tt/1E0cKMV

Moffitt researchers identify protein pathway involved in brain tumor stem cell growth

Glioblastomas are a highly aggressive type of brain tumor, with few effective treatment options. Researchers are one step closer to understanding glioblastoma development following the identification of a key protein signaling pathway involved in brain tumor stem cell growth and survival.

http://ift.tt/1LKHctu

Boosting myelin synthesis

Damage to myelin, the fatty insulator that enables communication between nerve cells, characterizes multiple sclerosis and other devastating neurological diseases. The damage doesn't come all at once: There is a "honeymoon" period during which some regeneration of myelin, called remyelination, does occur, but this ability to regenerate dissipates as the disease progresses and the patient ages.

http://ift.tt/1JRcenS

Regenerative Medicine Market Will Reach $4.8bn In 2015 According" Says New Visiongain Report

PRLog - Feb. 26, 2015 - LONDON -- LONDON, UK, 3rd of February 2015: A new report by visiongain calculates that the global translational regenerative medicine market will reach $4.8bn in 2015 with revenues showing growth to 2025. These revenue forecasts and others appear in visiongain's latest report Translational Regenerative Medicine: Market Prospects 2015-2025.

http://ift.tt/1AwypK2

Fate Therapeutics To Present At Cowen and Company 35th Annual Health Care Conference

Fate Therapeutics, Inc. , a biopharmaceutical company engaged in the development of programmed cellular therapeutics for the treatment of severe, life-threatening diseases, today announced that Christian Weyer, M.D., M.A.S., President and Chief Executive Officer, will present at the Cowen & Company 35th Annual Health Care Conference on Wednesday, March 4, 2015 at 11:20 am EST in Boston, MA. A live webcast of the presentation will be available through the investor relations section of the Company's website at http://ift.tt/1psDMU5 .

http://ift.tt/1LKg4en

Cellular Dynamics To Host Fourth Quarter And Full Year 2014 Financial Results Webcast And Call

... of cellular therapeutics. CDI was founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research at the University of Wisconsin-Madison. CDI's facilities are located in Madison, Wisconsin, with a second facility in Novato, ...

http://ift.tt/1LKg3XQ

Small molecule helps get stem cells to sites of disease and damage

IMAGE: Researchers identified a small molecule that can be used to program mesenchymal stem cells to home in on sites of damage. view more Bioengineers from Brigham and Women's Hospital with collaborators at the pharmaceutical company Sanofi have identified small molecules that can be used to program stem cells to home in on sites of damage, disease and inflammation.

http://ift.tt/1JR5AxZ

Cardio3 BioSciences To Raise Capital Via A Private Placement Of New Shares

Cardio3 BioSciences , a leader in the discovery and development of cell therapies, announces today the launch of a private placement of new ordinary shares to institutional investors. Cardio3 BioSciences intends to raise up to a maximum of 713,380 new shares .

http://ift.tt/1DuM3gH

Our blood may help keep us younger

Who doesn't want a way to stay looking and feeling young? Scientists are working on it. Even if you take looking younger out of the equation, how about being able to keep your bones strong, and your mind sharp? "There's this sort of long term communication that's happening through a number of different substances that are traveling in the blood and are sort of telling different parts of the body how old you are," said Dr. Amy Wagers, PhD, a Harvard Stem Cell Institute researcher.

http://ift.tt/1DWOppQ

Reasons for ibrutinib therapy discontinuation in patients with chronic lymphocytic leukemia

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology . CLL is the most prevalent leukemia in adults and it is not considered curable without an allogeneic stem cell transplant .

http://ift.tt/1E03CYP

Researchers identify protein pathway involved in brain tumor stem cell growth

Stem cells may save lives, dentist says

John W. Vollenweider, a general practice dentist, tends to patient Blake Lowry at his office in August 2014.

http://ift.tt/1LMCYn8

Reasons for ibrutinib therapy discontinuation in patients with chronic lymphocytic leukemia

About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology . CLL is the most prevalent leukemia in adults and it is not considered curable without an allogeneic stem cell transplant.

http://ift.tt/1DZYS5l

Moffitt researchers identify protein pathway involved in brain tumor stem cell growth

Ng: Scientific breakthroughs

... and in 2013, GSK shuttered the product. In the last few years, we have also had a lot of write-ups about stem cell research, which promises longer and healthier lives. It seems like this development is accelerating. Google is funding a venture with ...

http://ift.tt/1LMoWlD

Ocata Therapeutics Approved for Listing on NASDAQ

Ocata Therapeutics, Inc. , a clinical stage biotechnology company developing regenerative ophthalmology therapeutics, today announced that it has received notice that the NASDAQ Listing Qualifications Department has approved its application to list the Company's common stock on the NASDAQ Global Market, effective with the opening of trading today, February 26, 2015, under the ticker symbol "OCAT". "This is a significant step in the Company's evolution and crucial to our long-term corporate strategy," stated Ted Myles, Chief Operating Officer and Chief Financial Officer, of Ocata.

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Biophysicist receives EliteForsk Award 2015

Eliteforsk award Biophysics professor Lene Oddershede of the University of Copenhagen's Niels Bohr Institute at the Faculty of Science will receive an EliteForsk Award - Denmark's largest public research award - on Thursday, February 26. Lene Oddershede's work mainly focuses on an interdisciplinary research domain where physics, biology and medicine merge. Among other things, award funding will go to build new equipment that will be used to better understand how the development of stem cells can be steered for the benefit of patients worldwide.

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RowanSOM researcher awarded NINDS grant to develop stem cell-based therapy for Canavan disease

Paola Leone, PhD, the director of the Cell and Gene Therapy Center and a professor of Cell Biology at the Rowan University School of Osteopathic Medicine , has been awarded a three-year, $477,000 grant from the National Institute of Neurological Disorders and Stroke to develop a stem cell-based therapy for Canavan disease, a rare but devastating neurological disorder in children that typically takes a child's life by age 10. "Canavan disease is a fatal, inherited disease caused by a mutation in the aspartaocylase gene," Dr. Leone explained.

http://ift.tt/1ANCbxt

Calgary Sun Sunday March 1st 2015

The best news we have heard in a while from the hockey world was the remarkable recovery of hockey legend Gordie Howe after stem cell treatment and some great care by doctors here and abroad, and now The Gordie Howe C.A.R.E.S. PRO_AM Hockey tournament is returning to Calgary. This world-class event puts together regular Joe weekend warriors like you and me and some of the greatest that have ever played the game all in aid of charity.

http://ift.tt/1DWkUEy

Graphene shows anticancer potential

Scientists have discovered that the nanomaterial graphene can target and neutralize cancer stem cells and is not toxic to healthy cells, suggesting it may have potential to treat a range of cancers with fewer side-effects than many current treatments. Cancer stem cells are precursor cells that can self-renew and differentiate into cancer cells and form tumors.

http://ift.tt/1DWbRU2

Scientists find new links between inflammation and tissue regeneration

Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair - a process that is generally understood but remains mysterious in its particulars. Writing in the February 25 online issue of Nature , an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.

http://ift.tt/1BzlEk8

'Record visitors' at German Market

A record number of visitors came to Birmingham during the six weeks the city's Christmas German Market was open, latest figures have shown. About 5.5 million visitors contributed towards the A 397m spent, nearly double the A 201m generated in 2012, Visit Birmingham said.

http://ift.tt/1wi8kcc

Erin Fights Multiple Sclerosis - Interview on ExcitementRadio.com

Erin Castillo is seeking stem-cell & chemotherapy via a procedure known as HSCT or hematopoietic stem cell treatment, in hopes to cure her Multiple Sclerosis, is interviewed by Angela Beasley of ExcitementRadio on GetChaMindRight Feb 26 at 7pm EST PRLog - Feb. 25, 2015 - MIAMI -- This Thursday at 7pm Est Tune into Excitement Radio as Radio host Angela Beasley interviews Erin Castillo to talk about her battle against Multiple Sclerosis Erin's Story: While living in Texas, in the year 2000, I began noticing symptoms of numbness from my waist down. I went to my family doctor to find out what was going on and they thought I might have injured my back/spinal tissue.

http://ift.tt/180fEDb

Wednesday, February 25, 2015

UW Health research team closes in on cure for blindness

In a research lab at the McPherson Eye Research Institute, Dr. David Gamm and a team of researchers are looking for a cure and treatment for blinding diseases. A few miles away, the Valentyn family is waiting and hoping that a cure can be found because it would dramatically change the life of their daughter, Kenzi.

http://ift.tt/1zJu0j9

Parkinson's Institute Hosts Fundraising Walk April 12th To Fight Parkinson's Disease

The Parkinson's Institute and Clinical Center will host their inaugural fundraising walk to benefit individuals living with Parkinson's disease on Sunday, April 12, 2015, in Sunnyvale, CA. PRLog - Feb. 25, 2015 - SUNNYVALE, Calif.

http://ift.tt/1JNNUUa

Genome Editing of a CArG Element in the Mouse Genome Establishes its...

From the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA; and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA. present the use of a novel clustered regularly interspaced short palindromic repeat -CRISPR-associated 9 method to inactivate the calponin-1 gene involved in smooth muscle contraction, by introducing a knockin mutation to cleanly disrupt a CC 6GG element in the first intron of the gene.

http://ift.tt/1JO8sM3

Presentation Videos from Rejuvenation Biotechnology 2014

Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is medical biotechnology: progress towards repair and reversal of the known root causes of aging.

http://ift.tt/1JO3f79

Plea to help fund stem-cell treatment for Andrea Campbell

Andrea Campbell is worried that she will not be able to raise the money she needs for a treatment that will slow the effects of her multiple sclerosis and provide her with a better quality of life. Having battled the disease for the past 24 years, she said the onset has been slow and it has taken almost 10 years for it to affect her quality of life.

http://ift.tt/1LFkDqd

Systemic sclerosis patients with unhealed digital ulcers benefit from fat cell transplant

Digital ulcers are a frequent, painful, and quality of life altering complication for patients with systemic sclerosis , a connective tissue disease causing a progressive loss of small blood vessels and resulting changes in organs and tissues. DUs on the fingertips of SSc patients are slow to heal, if they heal at all, as many are unresponsive to any therapies.

http://ift.tt/1LEN1sF

Skin biopsies from people with Parkinsons and Alzheimers could help diagnose dementia

... are already proving useful in dementia research in other ways, for example at Alzheimer's Research UK's Stem Cell Research Centre. 'Human nerve cells can be grown in a dish from "reprogrammed", donated skin cells to create a model of Alzheimer's ...

http://ift.tt/17zDbuI

The Miami Stem Cell Treatment Center Announces Adult Stem Cell Public ...

The Miami Stem Cell Treatment Center announces a series of free public seminars on the use of adult stem cells for various degenerative and inflammatory conditions. They will be provided by Dr. Thomas A. Gionis, Surgeon-in-Chief and Dr. Nia Smyrniotis, Medical Director.

http://ift.tt/1ALT5N3

A former Boston mayor and U.S. ambassador to the Vatican said his life's work now is being an advocate for the use of adult stem cells in research and treatment of diseases. Raymond Flynn, who was ambassador from 1993 to 1997, spoke with Catholic News Service about adult stem cells and bioethical issues in medical research as well as his own struggles on the issue.

http://ift.tt/1AsrgdM

Politics, science, and public attitudes: What we're learning, and why it matters

... aspects of genomic medicine. For conservatives, hot-button issues include climate change, evolution, and stem cell research, with vaccination a recent addition. Ideology isn't the same thing as party affiliation, although the current gridlock in ...

http://ift.tt/1DWFwhv

How Pluripotent Stem Cells Are Grown Affects Their Genetic Stability

Human pluripotent stem cells, which include both human embryonic stem cells and adult stem cells like induced pluripotent stem cells , need large numbers for transplantation into patients but the process of translating their potential into effective, real-world treatments involves deciphering and resolving a host of daunting complexities, according to a new study. The authors say they have definitively shown that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.

http://ift.tt/1wf9SDU

Rowan Researcher Targets Stem Cell-Based Therapy for Rare Childhood Disease

Same-Sex Parent Babies By 2017 By Charlotte Lytton

Pioneering stem cell research undertaken at the University of Cambridge, UK and Weizmann Institute of Science in Israel were able to create primordial germ cells -which go on to become eggs and sperm-using human embryonic stem cells. While the same process had previously been carried out among rodents, this is the first time it has been successfully trialled with human matter, which could be entirely transformative for the future of conception.

http://ift.tt/1al5tuN

Sperm and egg created from skin cells of two same sex adults

Scientists from the UK and Israel have demonstrated for the first time that it is possible to make human egg and sperm cells using skin from two adults of the same sex - a breakthrough that may make it possible for same-sex couples to have children with shared DNA. The research, which was funded by the Wellcome Trust, was completed at Cambridge University with the assistance of experts from the Weizmann Institute of Science, Cambridge News reported on Monday.

http://ift.tt/1DWqgBf

Researchers find link between inflammation, tissue regeneration and wound repair response

Link between inflammation, tissue regeneration and wound repair response

New links between inflammation and regeneration have been found by scientists, including new information on signaling pathways that are activated by a receptor protein called gp130. Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair -- a process that is generally understood but remains mysterious in its particulars.

http://ift.tt/1ERird4

Mechanistic insight into immortal cells could speed clinical use

The mechanistic understanding of the relatively new technique for growing cells in culture indefinitely - known as conditional reprogramming - has been deciphered and reported in the February 25th issue of PLOS ONE . Researchers at Georgetown Lombardi Comprehensive Cancer Center say identifying the mechanisms of immortalization lays the groundwork for future clinical use of these cells.

http://ift.tt/1AL8uNv

Parents' Weekend 2015 opens Friday

... inspiring artwork and the communal spaces that help build a collaborative culture. The Lorry I. Lokey Stem Cell Research Building , located on the Stanford School of Medicine campus, will open its doors for a behind-the-scenes tour and will give ...

http://ift.tt/17yPl7f

Supreme Court rejects stem cell patent...

A nine-year legal challenge to human embryonic stem cell patents ended Tuesday , when the Supreme Court declined to hear the case. The decision means the Wisconsin Alumni Research Foundation, or WARF, will get to keep its patent rights for the cells, which were discovered in 1998 by University of Wisconsin - Madison scientist James Thompson .

http://ift.tt/1ah0tr3

New Study Shows Safer Methods for Stem Cell Culturing

February 25, 2015 - A new study led by researchers at The Scripps Research Institute and the University of California , San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations. The study points researchers toward safer and more robust methods of growing stem cells to treat disease and injury.

http://ift.tt/1vzEh4R

Culture Clash: How Stem Cells Are Grown Affects Their Genetic Stability

MD Anderson Names Hwu as Head of Cancer Medicine

Hwu's selection came after a competitive national search to fill the position currently being served by Richard Champlin, M.D., on an ad interim basis. Champlin will continue to serve as chair of Stem Cell Transplantation and Cellular Therapy.

http://ift.tt/1vzEgOh

Researchers Find Link Between Inflammation, Tissue Regeneration and Wound Repair Response

New study shows safer methods for stem cell culturing

University of Tokyo Researchers Hone In On Stem Cell That Speeds...

Ocata Therapeutics Receives Two New Patents For Immune-Modulatory Cell Technology

Ocata Therapeutics, Inc. , a leader in the field of Regenerative OphthalmologyTM, today announced that the United States Patent and Trademark Office issued two U.S. Patents, Nos. 8,962,321 and 8,961,956, directed to the Company's Hemangio-derived Mesenchymal Cells .

http://ift.tt/1woYLy6

Sartorius Stedim Biotech Release: New ambr Bioreactor Systems...

... bioprocess development and GMP manufacture of biologics and cell therapies, as well as discovery and stem cell research programmes. Contacts: Dominic Grone Senior Manager Corporate Communications, Sartorius Stedim Biotech Tel: +49 (0)551.3083324 ...

http://ift.tt/1ALgDBI

New Director Joins Regeneus Board Of Directors

Regenerative medicine company, Regeneus Ltd is pleased to announce the appointment of Dr Glen Richards as an independent non-executive director of Regeneus with effect from April. Dr Richards was the founding Managing Director of Greencross and over 20 years built it into Australia's largest veterinary healthcare group with over 115 veterinary practices and 195 vet specialty stores and led its merger with Petbarn.

http://ift.tt/1we2EAd

ViaCyte, Inc. (Formerly Known as Novocell, Inc.) To Present At 35th...

A Phase 1/2 trial called STEP ONE, or ViaCyte is a privately-held regenerative medicine company focused on developing a novel cell therapy for the treatment of diabetes. ViaCyte is conducting a Phase 1/2 clinical trial of the Company's VC-01 lead product candidate in patients with type 1 diabetes who have minimal to no insulin-producing beta cell function.

http://ift.tt/1FtKcZ3

Blood drive will again benefit 9-year-old cancer patient

Nine-year-old Isabella "Bella" Carabin-Lindgren will again be the beneficiary of Penn State New Kensington's semiannual community Blood Drive from 9 a.m. to 3 p.m. Wednesday, April 1, in the campus Art Gallery. Bella, a fourth-grader at Mary Queen of Apostles School in the nearby city of New Kensington, was diagnosed with Ewing's sarcoma when she was 10 months old.

http://ift.tt/1ALh271

Excess vitamin A may prevent foetal formation of blood cells

The study increases our understanding about why excess vitamin A is harmful but current recommended limits are still safe, say researchers Excessive retinoic acid - a molecule derived from vitamin A - can prevent the healthy development of blood in embryos, a team of Swedish researchers have found. While past studies have established that excessive vitamin A intake can be dangerous for the foetus - with recommended limits of intake for pregnant women adjusted accordingly - the effect on blood was previously unknown.

http://ift.tt/1woYZVZ?

New ambrA Bioreactor Systems Enhanced with Software for Design of Experiments

... bioprocess development and GMP manufacture of biologics and cell therapies, as well as discovery and stem cell research programmes. Dominic Grone Senior Manager Corporate Communications, Sartorius Stedim Biotech Tel: +49 (0)551.3083324 This e-mail ...

http://ift.tt/1DUgRs8

Previously Unknown Effect Of Vitamin A Identified, Lund University Study

Researchers at Lund University in Sweden have identified a previously unknown effect of vitamin A in human embryonic development. Their findings show that vitamin A affects the formation of blood cells.

http://ift.tt/17ysgkY

City to lease former Mayo Clinic space to Cardio3

This has been in the works for quite a while. It looks like it's now a done deal, at least on the city, RAEDI and DEED side.

http://ift.tt/1woAoQR

Ocata Therapeutics Receives Two New Patents for Immune-modulatory Cell Technology

Scientists grow leg muscle from cells in a dish

A team of researchers from Italy, Israel and the United Kingdom has succeeded in generating mature, functional skeletal muscles in mice using a new approach for tissue engineering. The scientists grew a leg muscle starting from engineered cells cultured in a dish to produce a graft.

http://ift.tt/1BTtFA1

Researchers Hone in on Stem Cell that Speeds Healing of Stubborn Diabetes Wounds

A new study published in the latest issue of STEM CELLS Translational Medicine reveals how a particular type of stem cell generated from fat tissue may outperform other types of stem cells in speeding up the healing of wounds caused by type 1 diabetes. These cells can be achieved in large amounts with minimal morbidity and could be a practical tool for a variety of stem cell-depleted or ischemic conditions of various organs and tissues.

http://ift.tt/1woefCl

Interviewing a Researcher Working on Stem Cells and Aging

Susy Gage Releases not Easy Being Green

Clumsily scribbling in a notebook while wearing two pairs of rubber gloves, scientist and author Susy Gage spent two months shadowing researchers in a Biosafety Level 3 labthe level below space suitsfor her newest novel, Not Easy Being Green . The book was originally intended to explore marginal treatments for incurable diseases.

http://ift.tt/1zHbfga

Health Minister Leo Varadkar: 'Commercial surrogacy will be banned in Ireland under new law'

... have published the heads of bill relating to infertility treatments, surrogacy and the permitting of stem cell research. The draft heads of bill will go out for a period of public consultation before going in front of Oireachtas health committee, ...

http://ift.tt/17xlqwl

Skin test 'could detect dementia'

... are already proving useful in dementia research in other ways, for example at Alzheimer's Research UK's Stem Cell Research Centre. "Human nerve cells can be grown in a dish from 'reprogrammed', donated skin cells to create a model of Alzheimer's ...

http://ift.tt/1AJuacN

'Not Easy Being Green,' Susy Gage's Tale of Mutant...

"Not Easy Being Green," Susy Gage's Tale of Mutant Viruses and Unscrupulous Medical Research, Now Available from Bitingduck Press Driven by ego, or money, or a genuine desire to help the desperate, practitioners all over the world are offering untested and often dangerous cures. "Not Easy Being Green," the second in Susy Gage's lab-lit series from Bitingduck Press, is an in-depth look into sketchy science in a fictional format, which goes on sale in print and electronic format today.

http://ift.tt/1Bbj02g

New Commentary from Asymmetrex LLC Director Anticipates Forthcoming...

... specific biomarkers for tissue stem cells. There is a significant unmet need for such invaluable tools in stem cell research, drug development, and regenerative medicine. Asymmetrex, LLC is a Massachusetts life sciences company with a focus on ...

http://ift.tt/1wbCLRw

Chromatin architecture reorganization during stem cell differentiation

To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. CiteULike organises scholarly papers or literature and provides bibliographic for universities and higher education establishments.

http://ift.tt/1DRZ5HG

Forging ahead in stem cell research

Japan's Shinya Yamanaka and Britain's John Gurdon won the Nobel Prize for Medicine in 2012 for their groundbreaking work on stem cells. - Filepic STEM cell research has recently picked up speed again following encouraging trials in the last few years, and Malaysia aims to keep up with the global pace in both the research and regulatory aspects.

http://ift.tt/1AIWdco

Love blossoms for Ainslie and Troy

IT might seem a bit clichA d, but love bloomed from a chance meeting between Troy Eccleston and his now fiancA Ainslie Sackey at the Albion Park Community Centre nearly three years ago. Ainslie Sackey and Troy Eccleston pictured at the Albion Park Community Garden on Tuesday.

http://ift.tt/1EPaEwh

Human non-small cell lung cancer expresses putative cancer stem cell...

Background Despite significant advances in staging and therapies, lung cancer remains a major cause of cancer-related lethality due to its high incidence and recurrence. Clearly, a novel approach is required to develop new therapies to treat this devastating disease.

http://ift.tt/17wIUSh

Tuesday, February 24, 2015

Dissecting neural differentiation regulatory networks through epigenetic footprinting

Models derived from human pluripotent stem cells that accurately recapitulate neural development in vitro and allow for the generation of specific neuronal subtypes are of major interest to the stem cell and biomedical community. Notch signalling, particularly through the Notch effector HES5, is a major pathway critical for the onset and maintenance of neural progenitor cells in the embryonic and adult nervous system.

http://ift.tt/1AIFQwC

Nazareth, URMC, others to research medical device

Nazareth College, the University of Rochester Medical Center, Monroe Community Hospital and Ohio State University plan to join forces in a research project to test Gorbel Medical's SafeGait physical therapy device, officials of the organizations said last week. A division of the Victor-based industrial crane and lifting device maker Gorbel Inc., Gorbel Medical's newly developed SafeGait device applies technology developed for industrial material handling to the suspension harnesses used by physical therapists to help patients who have lost the ability to walk.

http://ift.tt/1D9mBKO

Fundraiser to Raise Money for Local Mom's Stem Cell Transplant

Before she was diagnosed with the disease in October of 2012, Garcia held full-time and part-time jobs, ran her household and took care of her 5-year-old daughter Gracelynn. "I lost my mom when I was 10 from cancer and I refuse to let this happen to my daughter," Garcia wrote on her Go Fund Me page.

http://ift.tt/1DQsAtp?

Our blood may help keep us younger

Stem Cell Breakthrough Opens Door For Two-Dad Babies

An international team of scientists have shown that it is possible to create human sperm and eggs from stem cells derived from adult skin, regardless of the donor's gender. While this breakthrough could help men and women who have been rendered infertile by disease, gay groups have also expressed hope that this project will eventually lead to the creation of children made from same-sex parents.

http://ift.tt/1af8VXU

DNA Transcription Sheds Light on Cancer Pathogenesis

Transcription, the process in which genetic information from DNA is copied into RNA to produce proteins, requires many pieces coming together. In four recent publications, Ali Shilatifard, PhD, Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, examined how the misregulation of these pieces can lead to cancer.

http://ift.tt/1LAkNz4

The receptor protein tyrosine phosphatase, PTP-RO, is upregulated...

The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document.

http://ift.tt/1LAkNiH

Previously unknown effect of vitamin A identified

A previously unknown effect of vitamin A in human embryonic development has been identified by researchers, indicating that vitamin A affects the formation of blood cells. Researchers at Lund University in Sweden have identified a previously unknown effect of vitamin A in human embryonic development.

http://ift.tt/1wl621H

Researchers Say Same-Sex Couples May Soon Be Able to Produce Biological Children Together

Well this is a game-changer if I ever heard one: Scientists say that same-sex couples may soon be able to produce biological children together. Researchers at Cambridge University and Israel's Weizmann Institute of Science say they have discovered a way to "create human egg and sperm cells from the stem cells in the skin of two adults."

http://ift.tt/1zDV9E5

Stem Cell Breakthrough Opens Door For Two-Dad Babies In As Little As 2 Years

To Bring CRISPR Gene Editing to Rare Blood Cancer, MPN Genetics...

Announcing a fistful of Foundation $200,000 research grants, a small patient advocacy group has formed MPN Genetics to help bring new gene editing technologies to a rare blood cancer. mGEN is supported by an elite international group of blood cancer scientists and specialists.

http://ift.tt/1LCTJBg

Stem Cell Breakthrough Opens Door To Gay Couples Having Their Own Babies

A stem cell research study at Cambridge University , England has potentially opened the door to same-sex couples having their own babies, reports CBS Atlanta . The breakthrough achieved in the study shows that fully "manufactured" babies can be created from the skin cells of two adults of the same gender.

http://ift.tt/1JHDvco

Gene regulatory path revealed as target for therapy of aggressive pediatric brain cancer

Working with cells taken from children with a very rare but ferocious form of brain cancer, Johns Hopkins Kimmel Cancer Center scientists have identified a genetic pathway that acts as a master regulator of thousands of other genes and may spur cancer cell growth and resistance to anticancer treatment. Their experiments with cells from patients with atypical teratoid/rhabdoid tumor also found that selumetinib, an experimental anticancer drug currently in clinical trials for other childhood brain cancers, can disrupt part of the molecular pathway regulated by one of these factors, according to a research team led by Eric Raabe, M.D., Ph.D., an assistant professor of oncology at the Johns Hopkins University School of Medicine.

http://ift.tt/1LC4Ryb

Eye development: Morphogenesis through flowing tissue

... coloboma develops. And we found the source of the stem cells in the eye, which is of major importance in stem cell research," explains Prof. Wittbrodt. The eye is an outgrowth of the brain and forms in the embryo from a sac-like vesicle that quickly ...

http://ift.tt/1DOBlUW

Ocata Therapeutics to Present at 2015 Cowen Health Care Conference

Ocata Therapeutics, Inc. , a leader in the field of regenerative ophthalmology, today announced that that Paul Wotton, Ph.D., President and Chief Executive Officer, will present a company overview at the 2015 Cowen Health Care Conference on Tuesday, March 3, 2015 at 9:20 a.m. ET in Boston. A live audio webcast of the presentation will be available via the "Investor Relations" page of the Ocata website, www.ocata.com .

http://ift.tt/1Bm7e6V

Previously unknown effect of vitamin A identified

The signal molecule, retinoic acid, is a product of vitamin A which helps to instruct how different types of tissue are to be formed in the growing embryo. For the first time, Professor Niels-Bjarne Woods' laboratory, Lund Stem Cell Center in Sweden, has studied the effects of retinoic acid in relation to how blood cells develop from human stem cells.

http://ift.tt/1GoMQjY

Morphogenesis through flowing tissue

Research with space explorers may one day heal Earth's warriors

... surgery and orthopedic surgery and member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. Soo is also research director for UCLA Operation Mend, an organization devoted to providing medical care for wounded ...

http://ift.tt/1acr9t5

The generation of sex cells

Primordial germ cells are the earliest population of germ cells established during embryonic development and constitute the beginning of the totipotent state. A recent study provides a new protocol for the efficient generation of PGC-like cells from human embryonic stem cells, providing an in vitro platform to study human PGC differentiation and specification.

http://ift.tt/17SlJBv

ESPERITE (Euronext ESP) pioneers first treatment worldwide of...

The clinical trial aims to demonstrate safety and preliminary efficacy of sequential intravenous infusion of the ex vivo expanded mesenchymal stem cells derived from cord tissue and the cord blood stem cells. The study will use, for the first time in clinical research, autologous MSC derived from cryopreserved cord tissue.

http://ift.tt/1w6C6Rk

Stress Causes Stem Cells To Age

Under conditions of stress such as chronic blood loss or infection, hematopoietic stem cells are driven into a state of rapid cell division to produce new blood cells and repair damaged tissue. Under normal conditions, many of the different types of tissue-specific adult stem cells, including hematopoietic stem cells, exist in a state or dormancy where they rarely divide and have very low energy demands.

http://ift.tt/1w6MdWi

Global Stem Cells Group, Inc. Announces Launch of New Stem Cell Harvesting Products

... Cells Group, Inc. is the parent company of six wholly owned operating companies dedicated entirely to stem cell research, training, products and solutions. Founded in 2012, the company combines dedicated researchers, physician and patient educators ...

http://ift.tt/17RgSRj

Research With Space Explorers May One Day Heal Earth's Warriors

... surgery and orthopedic surgery and member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. Soo is also research director for UCLA Operation Mend , an organization devoted to providing medical care for wounded ...

http://ift.tt/1FSchgv

Characterization and chromosomal localization of PTPRO, a novel...

Hematopoietic stem cells support blood cells throughout life by utilizing their self-renewing and multilineage differentiating capabilities. Hematopoietic growth factors mediate their effects on stem cells by the tyrosine phosphorylation of proteins.

http://ift.tt/1a9N7wA

Monday, February 23, 2015

Now Same Sex Couples Can Have Babies

Stem cells from the skin of two adults of the same sex can be used to make human egg and sperm cells, new research has shown. Azim Surani, professor of physiology and reproduction at Cambridge University and head of this project, has along with his colleagues has made these very early human stem cells in a dish.

http://ift.tt/1AEpQf0

Stem cell breakthrough may allow same gender couples to create babies

Researchers have developed a technique that could allow a baby to be created from the combination of two adults, no matter their gender Researchers from Cambridge University and Israel's Weizmann Institute of Science are claiming a stem cell research breakthrough that would allow a baby to be created from the skin cells from two adults, no matter their gender. This potentially allows for infertile couples to have their own children without resorting to sperm or egg donors, and may provide the means for same sex couples to produce their own babies.

http://ift.tt/1MNRuMU

Volunteer uses website to fund medical expenses for herself and Chihuahua

A volunteer who works to assist missing/murdered cases has discovered an online fundraiser . She is using a special website called gofundme in an attempt to raise money for medical expenses for herself and her Chihuahua .

http://ift.tt/1EKzbmk

Study nearly triples the locations in the human genome that harbor microRNAs

According to the public databases, there are currently approximately 1,900 locations in the human genome that produce microRNAs , the small and powerful non-coding molecules that regulate numerous cellular processes by reducing the abundance of their targets. New research published in the Proceedings of the National Academy of Sciences this week adds another roughly 3,400 such locations to that list.

http://ift.tt/1LwfkcA

Georgia Right to Life Backs Embryo Bill

... have been successfully used to treat more than 70 human illnesses. "Smart money is going to support adult stem cell research over destructive stem cell research because of its higher return on investment." Failure to approve this bill could allow ...

http://ift.tt/1a6eCqZ

Study: Stem Cell Breakthrough Opens Door To Same-Sex Couples Having Their Own Babies

... With one of the largest, most veteran local news staffs in the country, WAOK [] ATLANTA (CBS ATLANTA) - A stem cell research breakthrough achieved by Cambridge University shows the first fully "manufactured" baby can be created from the skin cells ...

http://ift.tt/1wgrJjz

Esi Bio ??? a Division Of BioTime, Announces Alliance Agreement...

ESI BIO, the stem cell products division of BioTime, Inc., providing stem cells and stem cell research reagents world-wide, and Pivotal Scientific Ltd, a company specializing in developing the international growth of biotech enterprises, announced an alliance agreement to develop business opportunities and manage ESI BIO's growing network of new international distributors. "not just in terms of excellent products, but their focus on clinically-relevant products is a novel selling point, especially as researchers are looking to treat and cure disease.

http://ift.tt/17O6JEX

ViaCyte, Inc. (Formerly Known as Novocell, Inc.) To Present At Two...

Esi Bio - a Division of BioTime, Inc., Announces Alliance Agreement ...

ESI BIO, the stem cell products division of BioTime, Inc., providing stem cells and stem cell research reagents world-wide, and Pivotal Scientific Ltd, a company specializing in developing the international growth of biotech enterprises, announced an alliance agreement to develop business opportunities and manage ESI BIO's growing network of new international distributors. ESI BIO's research products are used by stem cell researchers around the world and include clinical and research grade human embryonic stem cells from ES Cell International and HyStem hyaluronan-based hydrogel extracellular matrices.

http://ift.tt/1DdGW4k

Press release distribution, EDGAR filing, XBRL, regulatory filings

... Stem Cell Products )--ESI BIO, the stem cell products division of BioTime, Inc., providing stem cells and stem cell research reagents world-wide, and Pivotal Scientific Ltd, a company s... )--TaquaA , LLC, a leading supplier of mobile and fixed ...

http://ift.tt/1AmXHdv

Make Canada a magnet for stem cell trials

... Ontario Institute for Regenerative Medicine and immediate past president of the International Society for Stem Cell Research. Three weeks ago, people across the nation watched Gordie Howe, Canada's legendary Mr. Hockey, return home to Saskatchewan ...

http://ift.tt/1LupvhI

amfAR announces $100 million investment strategy aimed at curing HIV

The establishment of the amfAR Institute for HIV Cure Research within a major academic research institution with a grant of $20 million will be the centerpiece of the investment strategy. "This represents the greatest expansion of amfAR's grant making in the 30-year history of the Foundation," said Kevin Robert Frost, amfAR's Chief Executive Officer.

http://ift.tt/1JCcSpb

Study points researchers toward safer, more robust methods of growing stem cells

A new study led by researchers at The Scripps Research Institute and the University of California , San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations. The study points researchers toward safer and more robust methods of growing stem cells to treat disease and injury.

http://ift.tt/17MCBK0

RCMP, Health Canada investigate Winnipeg stem cell researcher

... by his Indian partners to "push me out and subsequently vilify me as part of a larger scheme to steal my stem cell research protocol and run with it." "Details of the conspiracy to discredit me are now emerging along with several inconsistencies and ...

http://ift.tt/1w1Ho0u

Adding Multimedia Revlimida (Lenalidomide) Approved by the European...

Celgene International Sarl, a wholly owned subsidiary of Celgene Corporation , today announced that the European Commission has approved REVLIMID for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for transplant. The REVLIMID Marketing Authorisation has been updated to include this new indication in multiple myeloma, building upon the already approved indication of REVLIMID in combination with dexamethasone for the treatment of multiple myeloma in adult patients who have received at least one prior therapy.

http://ift.tt/1DcljRS

CIRM's Klein proposes $100B biomed program

Bob Klein describes his vision of how to increase biomedical funding to hasten discovery and commercialization of disease treatments. He spoke Thursday, Feb. 19, at the annual UCSD Moores Cancer Center symposium.

http://ift.tt/1D1MPyR

ESPERITE (Euronext ESP) pioneers first treatment worldwide of...

CryoSave, part of ESPERITE, is the only private cord blood bank sponsoring a GCP clinical trial according to GMP-ATMP international guidelines CryoSave leads and sponsors a multicentre clinical trial following GCP- ICH standards, for investigation of new treatment of Cerebral Palsy using dual infusion of two types of stem cells derived from umbilical cord blood and cord tissue processed by CryoSave Geneva, Switzerland - 23 February 2015 The clinical trial aims to demonstrate safety and preliminary efficacy of sequential intravenous infusion of the ex vivo expanded mesenchymal stem cells derived from cord tissue and the cord blood stem cells.

http://ift.tt/1FhZRuG

Sunday, February 22, 2015

Computational Strategy Helps to Map Human Epigenome

... mark placement in human stem cells. The information their program uncovers will also help to guide future stem cell research. Wang, Whitaker, and many others from UC San Diego are among members of the Epigenomics Roadmap Consortium and are among the ...

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Autism Genes Activate During Fetal Brain Development

Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development. The research, led by Lilia Iakoucheva, PhD, assistant professor in the Department of Psychiatry, is published in the February 18 issue of Neuron.

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Mobile app with evidence-based decision support diagnoses more obesity, smoking, and depression

Smartphones and tablets may hold the key to getting more nurses to diagnose patients with chronic health issues like obesity, smoking, and depression -- three of the leading causes of preventable death and disability. Smartphones and tablets may hold the key to getting more nurses to diagnose patients with chronic health issues like obesity, smoking, and depression -- three of the leading causes of preventable death and disability.

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Ranibizumab reverses vision loss caused by diabetes

Ranibizumab, a prescription drug commonly used to treat age-related vision loss, also reverses vision loss caused by diabetes among Hispanic and non-Hispanic whites, according to a new study. Ranibizumab, a prescription drug commonly used to treat age-related vision loss, also reverses vision loss caused by diabetes among Hispanic and non-Hispanic whites, according to a new study led by investigators from the University of Southern California Eye Institute.

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New hope in the fight against pain: Analgesic drugs could be used to...

Drugs that selectively target the melatonin MT2 receptor represent a novel class of analgesic drugs that could be used to treat patients with neuropathic pain, an international study reports, for the first time. An international study led by scientists at McGill University reports, for the first time, that drugs that selectively target the melatonin MT2 receptor represent a novel class of analgesic drugs that could be used to treat patients with neuropathic pain.

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Older adults with limited mobility may lessen heart problems with activity

Every minute of physical activity may lower risk of heart attack or coronary death in older adults with limited mobility. The amount of activity appeared more important to predicted heart risk than the intensity of the activity, researchers say.

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Brave gran set to take on 10,000ft skydive to help pay for life-saving medical treatment for daughter

A GRAN who is afraid of heights is set to skydive from 10,000ft to help pay for life-saving medical treatment for her daughter. Margaret Clarke, 70, aims to overcome her lifelong fear so Lucy, 38, can travel to Moscow for a pioneering stem cell transplant to stop the progression of Multiple Sclerosis.

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Medical advances rely on stem-cell research

I once saw a particularly astute bumper sticker on the car of an outspoken high school science teacher. It read: "Support stem cell research; grow Bush a brain."

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Faversham's courageous Roisin Kelleher launches petition to make...

... the average age of survival is 41. Roisin said: "We truly believe research and clinical trials in adult stem cell research are worthy of high-level research. "Please sign the petition and share with family and friends so we can embark on the journey ...

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New Study Probes Into The Source of Stem Cell Aging and Damage

A microscopic view of bone marrow in an undated image. Stem cells taken from bone marrow replenished the radiation-ravaged immune systems and bone marrow of mice and can also make brain and liver cells, scientists reported on Monday.

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Female diet alters the nutrient composition of fluid in the womb

Scientists have discovered that maternal diet affects the nutrient composition of fluid in the womb of women and thus may aid in the development of nutritional interventions to support the very earliest stages of pregnancy. Scientists at the University of Soutahmpton's Faculty of Medicine have discovered that maternal diet affects the nutrient composition of fluid in the womb of women and thus may aid in the development of nutritional interventions to support the very earliest stages of pregnancy.

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New study shows safer methods for stem cell culturing

Certain stem cell culture methods are associated with increased DNA mutations, a new study shows. The study points researchers toward safer and more robust methods of growing stem cells to treat disease and injury.

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New study shows safer methods for stem cell culturing

Protein that repels immune cells protects transplanted pancreatic islets from rejection

A possible solution to limitations that have kept pancreatic islet transplantation from meeting its promise as a cure for type 1 diabetes has been developed by researchers. They report that encapsulating insulin-producing islets in gel capsules infused with a protein that repels key immune cells protected islets from attack by the recipient's immune system without the need for immunosuppressive drugs, restoring long-term blood sugar control in mouse models.

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Saturday, February 21, 2015

"Retinitis Pigmentosa (Retinitis) - Pipeline Review, H2 2014" Published

This report provides comprehensive information on the therapeutic development for Retinitis Pigmentosa , complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action , route of administration and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Retinitis Pigmentosa and special features on late-stage and discontinued projects.

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Next Magazine misses the mark in saying money, influence behind Leung Chuen-yan getting post at Karolinska Institute

Magazine's insinuation that money, influence were behind Leung Chuen-yan obtaining a post at Karolinska Institute off the mark The tabloid Next Magazine has the knives out for Chief Executive Leung Chun-ying again. But this time, it gets more personal than usual as it involves Dr Leung Chuen-yan, his newly minted PhD son.

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Vital breakthrough or scientists playing God? This Church leader is ...

... seen as irrelevant. Conservative Christians have opposed transplants, IVF, embryo experimentation and stem cell research. Furthermore, the Church and science are always portrayed as being at odds even though this is often a misreading of history. ...

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After delays, Kyle McConkey preparing once again for cancer treatment

WATCH: Thanks to the over $280,000 raised for his experimental cancer treatment, Delta teenager Kyle McConkey is set for a new round of treatment next month. Jennifer Palma reports.

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The Government will spend more than 300m on dementia research

... fundraising campaign which, in addition to our existing research projects, will see a pioneering new Stem Cell Research Centre, a powerful network of world-class Drug Discovery Institutes to fast-track new treatments and a Global Clinical Trials ...

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The Government will spend more than 300m on dementia research

Dementia gets 300m and training

Oligodendroglioma Therapeutics Pipeline Market H2 2014 Review Report...

RnRMarketResearch.com adds "Oligodendroglioma - Pipeline Review, H2 2014" report to its store. The report provides an overview of the oligodendroglioma's therapeutic pipeline.

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The Government will spend more than 300m on dementia research

Friday, February 20, 2015

Bioresearch Product Fairea Event At Uc Davis, Feb 25

... funding to improve cancer care A -Researchers at UC Davis have been granted $53 million in awards towards stem cell research This year, exhibitors will feature their new biotechnology, lab products and consumables at this popular event. Vendors for ...

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Dementia gets 300m and training

The Government will spend more than 300m on dementia research

Stem-cell advocate promotes global funding model for research

Some of the nation's top oncology researchers and private companies met Thursday at the University of California San Diego Moores Cancer Center for the 11th annual Industry/Academic Translational Oncology Symposium.

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Bone marrow transplantation: The ultimate exercise in matchmaking

Stanford Blood Center is home to one of the top human leukocyte antigen histocompatibility laboratories in the country. While the center is best known for supplying blood products to hospitals, SBC's HLA lab supports the success of hundreds of bone marrow transplants administered at Stanford Health Care by providing and developing tests to determine donor and recipient organ compatibility.

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Stem cell 'tool' grants given to five researchers

The awards are the third in the agency's "tools and technology" grants, which encourage researchers to develop new methods and techniques to overcome stumbling blocks in the field. Five Stanford researchers were awarded grants of between $1 million and $2 million each by the state stem cell agency at its most recent board meeting.

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DeZwirek's $2 Million Gift to Marcus Neuroscience Institute Names...

The gift will be used to fund programs, technology, and capital projects. The Marcus Neuroscience Institute contains four dedicated operating rooms, including one equipped with intraoperative MRI and two with intraoperative CT, capabilities found in only a handful of facilities across the country.

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Alabama ALS patients helped researchers find new ALS gene

Crestwood Medical Center's ALS Clinic has been named an ALS Association Certified Treatment Center of Excellence. Pictured at a Friday, May 16, 2014, announcement of the designation are, from left, Cassie Barber, executive director of the ALS Association's Alabama chapter; Pam Hudson, Crestwood CEO; Stuart Obermann, chairman of the board for the Alabama ALS chapter; Janet Thorn, director of care services for the ALS chapter; Dr. T.J. Mulpur; Sherry Koloddziejczak, director of Crestwood Therapy Services; Dr. Aruna Arora; and Marcia Obermann, ALS Care Clinic director.

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REVLIMIDR (Lenalidomide) Approved by the European Commission for the...

Feb 20, 2015--Celgene International Sarl, a wholly owned subsidiary of Celgene Corporation , today announced that the European Commission has approved REVLIMID R for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for transplant. The REVLIMID Marketing Authorisation has been updated to include this new indication in multiple myeloma, building upon the already approved indication of REVLIMID in combination with dexamethasone for the treatment of multiple myeloma in adult patients who have received at least one prior therapy.

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New insights into mechanisms that regulate DNA methylation patterning

The Journal of Experimental Biology , Vol. 218, No. 1. , pp. 14-20, doi:10.1242/jeb.107961 From a fertilised egg to a mature organism, cells divide and accumulate epigenetic information, which is faithfully passed on to daughter cells.

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Cutting off a cancer cell at its transcriptional source: Model system ...

What if you could attack cancer cells at their source without hurting the surrounding healthy cells? A group of researchers from the University of Virginia, the University of Massachusetts, Cornell University, and the University of Kansas constructed a small molecule inhibitor that targets a mutated protein present in leukemia cells, halting the progression of leukemia in both mouse models and in human cells. Their work appears in Science .

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Pre-Eclampsia Therapeutics Pipeline Market H2 2014 Review Report Available at RnRMarketResearch.com

RnRMarketResearch.com adds "Pre-Eclampsia - Pipeline Review, H2 2014" report to its store. The report provides an overview of the pre-eclampsia's therapeutic pipeline.

http://ift.tt/1GbOpBI

Progress and Problems in the Search for a Cure for HIV

Leading experts discussed the latest developments in the search for an HIV cure at a January Center for AIDS Research symposium in San Francisco, following a year of disappointing setbacks in the field. Researchers are increasingly focusing on a "functional cure" -- or remission -- that would allow people with HIV to remain off antiretroviral therapy for prolonged periods, as the hopes for true viral eradication have dimmed.

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New partnership aims to create stem cell resource to study psychiatric disorders

The New York Stem Cell Foundation and the Stanley Center at the Broad Institute of MIT and Harvard are partnering to create a foundational stem cell resource to study psychiatric disorders through the production of induced pluripotent stem cell lines from individuals with schizophrenia and other psychiatric disorders. This new partnership aligns NYSCF's mission to accelerate cures for the major disease of our time through stem cell research with the Stanley Center's goal to reduce the burden of serious mental illness through research.

http://ift.tt/1FBXUN5

IUPUI's Jason Meyer awarded $1.8 million NIH grant to explore how glaucoma develops in stem cells

... customized strategies to fix what's going wrong," Meyer said. He sees this as an exciting approach to stem cell research. Often, stem cells are transplanted to replace cells damaged by disease. While that's a possibility, Meyer's research instead ...

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A Roadmap for the human epigenome

The epigenome, a collection of chemical modifications that alter the way genetic information is used in different cells, has important roles in normal development and disease. A collection of papers from the Roadmap Epigenomics Program, published in Nature this week, charts these modifications in a number of human cell types.

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REVLIMIDA (Lenalidomide) Approved by the European Commission for the ...

Autism genes activate during fetal brain development

Cord-blood bank enters private arena

As the global market around umbilical cord blood stem-cell treatments reaches well into the billions of dollars annually, the University of Colorado has taken a pioneering step of sorts by expanding its own cord-blood banking services into the private realm. ClinImmune Labs, a company owned by CU and housed at the school's Anschutz Medical Campus in Aurora, has served as a public cord blood bank for 17 years.

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New study reveals why some children are born with autism

According to US, autism genes are activated during fetal brain development. Autism-related mutations are connected to a pathway that regulates brain development.

http://ift.tt/1AQlDYS

Renzi - one year on

One year on from ousting from party colleague Enrico Letta to become the youngest-ever prime minister since Fascist dictator Benito Mussolini, the go-getting Matteo Renzi is still the coolest kid on Italy's political scene. Even if he has fallen short of delivering the radical change he promised when he conquered power.

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Article Image

The White Horse in Brigg raised 723.80 for Brigg girl Ebony Smith. Ebony is pictured accepting the donation from White Horse staff Lois Hamill, second left, and Layla Moore, right, as, looking on, are Tammy Smith, White Horse manager Gavin Ellis and Ashley Steeper Ebony with, front from left, Yvonne Dean, Georgina Orwin and Claire Halsoll, and back from left, Tammy Smith, John Stephenson, Craig Hopkinson, Bonnie Wilson and Aaron Connah from Fair Gardens Plant Centre THE mother of a Brigg girl who suffers from cancer has thanked fundraisers for their support, ahead of a show tomorrow night.

http://ift.tt/1CR7cia

Thursday, February 19, 2015

Stanley Center at the Broad Institute and New York Stem Cell...

Induced pluripotent stem cell lines to be made from people with schizophrenia and other psychiatric disorders, to study cell changes The New York Stem Cell Foundation and the Stanley Center at the Broad Institute of MIT and Harvard are partnering to create a foundational stem cell resource to study psychiatric disorders through the production of induced pluripotent stem cell lines from individuals with schizophrenia and other psychiatric disorders. This new partnership aligns NYSCF's mission to accelerate cures for the major disease of our time through stem cell research with the Stanley Center's goal to reduce the burden of serious mental illness through research.

http://ift.tt/1LgflBb

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